Table 3.

Linear regression analyses assessing the interaction between childhood trauma and right hippocampal volume on chronic multisite musculoskeletal pain in individuals with 0, 1, or 2 FKBP5rs3800373 risk alleles (n = 25,280).

	0 risk alleles (n = 12,777)			1 risk allele (n = 10,464)			2 risk alleles (n = 2,039)
	β	S.E.	p	β	S.E.	p	β	S.E.	p
Intercept	−0.311	0.078	< 0.001	−0.260	0.084	0.002	−0.301	0.188	0.110
Right hippocampal volume	0.004	0.008	0.577	−0.012	0.008	0.158	−0.014	0.019	0.452
Childhood trauma severity	0.192	0.028	< 0.001	0.189	0.032	< 0.001	0.178	0.067	0.008
Age	0.0008	0.001	0.399	0.0007	0.001	0.520	0.002	0.002	0.331
Sex	−0.103	0.014	< 0.001	−0.105	0.016	< 0.001	−0.078	0.035	0.027
BMI	0.029	0.002	< 0.001	0.027	0.002	< 0.001	0.022	0.004	< 0.001
Genotyping array	0.020	0.024	0.408	0.001	0.026	0.972	0.0347	0.059	0.427
Imaging center (Reading)	−0.029	0.022	0.177	0.017	0.024	0.489	0.034	0.054	0.528
Imaging center (Newcastle)	0.004	0.018	0.803	0.035	0.019	0.074	0.152	0.043	< 0.001
Right hippocampal volume*childhood trauma severity	−0.020	0.028	0.470	−0.084	0.031	0.006	−0.168	0.083	0.042

Chronic multisite musculoskeletal pain was defined as the number of musculoskeletal sites with pain that persisted for 3 months or more, ranging from 0 to 4 sites. Genetic principal components 1–10 and ethnic background were included as covariates but omitted from the table for brevity.