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. 2022 Apr 20;13(4):380. doi: 10.1038/s41419-022-04825-6

Fig. 2. CXCR7 promotes CAF activation in transgenic mice.

Fig. 2

A The schematic regimen of colitis-associated cancer model by treatment with three cycles of AOM/DSS. Representative images of colons from AOM/DSS-treated WT (n = 8) and Villin-CXCR7 (CXCR7+/−) transgenic mice (n = 8). B Total polyp counts per mouse were examined in different groups (n = 8). **p < 0.01 vs. WT mice. C, D IHC analysis of the expression of α-SMA in colonic tissues of AOM/DSS-induced WT and Villin-CXCR7 (CXCR7+/−) transgenic mice and statistical analysis was performed. *p < 0.05 vs. WT mice (n = 6), scale bar = 50, 20 μm. E, F Western blot analysis of the expression of E-cadherin, Vimentin, α-SMA, FAP, and CXCR7 in colonic tissues of AOM/DSS-induced WT and Villin-CXCR7 (CXCR7+/−) transgenic mice normalized to β-actin and statistical analyses were performed. *p < 0.05, **p < 0.01 vs. WT mice.