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. 2022 Apr 20;13(4):380. doi: 10.1038/s41419-022-04825-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A, B Invasive capacity of CRC cells (HCT116 and SW620) co-cultured with CM from MRC-5 cells transfected with miR-146a-5p and miR-155-5p mimics (146m, 155m) was determined by transwell assay and statistical analysis was performed. **p < 0.01 vs. negative control (NC). C Western blot analysis of the expression levels of EMT-related proteins in HCT116 and SW620 cells treated with CM from MRC-5 cells transfected with miR-146a-5p and miR-155-5p mimics (146m, 155m). D Western blot analysis of the expression levels of EMT-related proteins in HCT116 and SW620 cells treated with CM from MRC-5 cells incubated with exosomes derived from CRC cells overexpressing CXCR7 and control. Densitometry and statistical analysis were performed. *p < 0.05, **p < 0.01 vs. control. E RT-qPCR analysis of IL-6, TNFα, TGFβ, and CXCL12 mRNA levels in MRC-5 cells transfected with miR-146a-5p and miR-155-5p mimics (146m, 155m) and inhibitors (146i, 155i). *p < 0.05, **p < 0.01 vs. negative control (NC). F RT-qPCR analysis of the mRNA levels of cytokines TNFα, IL-6, CXCL12, and TGFβ in MRC-5 cells treated with exosomes derived from HCT116^CXCR7 and SW620^CXCR7 cells and the corresponding controls. *p < 0.05, **p < 0.01 vs. control.