Skip to main content
. 2022 Apr 20;13(4):380. doi: 10.1038/s41419-022-04825-6

Fig. 8. The level of miR-146a-5p and miR-155-5p was higher in CRC tissues and serum exosomes compared with that of normal counterparts.

Fig. 8

A Levels of miR-146a-5p and miR-155-5p were determined in colonic tissues of CRC patients and adjacent normal colon tissues (n = 24). B RT-qPCR analysis of exosomal miR-146a-5p and miR-155-5p in the serum of CRC patients (n = 17) and healthy volunteers (n = 13). *p < 0.05, **p < 0.01 vs. control. C Western blot analysis of expression levels of CXCR7, FAP, and α-SMA in CRC patients with (n = 7) and without (n = 10) distant metastasis. D RT-qPCR analysis of exosomal miR-146a-5p and miR-155-5p in the serum of non-metastatic (n = 10) and metastatic (n = 7) CRC patients. *p < 0.05. E The scheme depicts the intercellular communications between CXCR7-overexpressing CRC cells and activation of CAFs through exosomal miRNAs.