Figure 2.

The role of liver cells in inflammation and liver damage. Liver cells help produce and activate immune cells by producing cytokines and inflammatory chemokines. On the other hand, hepatic stellate cells produce fibrosis of the liver tissue and lose their function by producing different components of the extracellular matrix and differentiation into myofibroblasts in inflammatory conditions; HSCs, hepatic stellate cells; KCs, Kupffer cells; LSECs, hepatic sinusoidal endothelial cells; HEPs, Hepatocytes; DCs, Dendritic cells; ECM, extracellular matrix; TXA2, Thromboxane A2; KLF2, Krüppel factor 2 transcription factor; TIMP, Tissue inhibitors of matrix metalloproteinases.