TABLE 1.
Parameters used for simulation of pharmacokinetic profiles
| Parametera | Estimate (SE) | Estimateb |
|---|---|---|
| CL/F (liter/kg/day) | 0.733 (0.051) | 0.704 |
| V/F (liter/kg) | 20.37 (2.53) | 20.56 |
| ωCL/F | 0.15 | 0.16 |
| ωV/F | 0.56 | 0.55 |
| Residual additive error (ςɛ [ng/ml]) | 180.4 |
a
CL/F, clearance divided by the fraction of drug absorbed; V/F, total apparent volume of distribution divided by the fraction of drug absorbed; ωCL/F and ωV/F, intersubject variability in CL/F and V/F, respectively, modeled with multiplicative error models.
b
Estimates obtained from nonlinear mixed-effects modeling of the 1,000 simulated pharmacokinetic profiles.