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Parameter estimates derived from population pharmacokinetic (C0 and k) and pharmacodynamic (γ and C50) modeling and a previously published article (a and k1)a
| Parameter | Estimate |
|---|---|
| P0 | 1012 |
| a | 1.15/day |
| k | 0.036/day |
| k1 | 3.45/day |
| C0 | 1,200 ng/ml (single dose of 25 mg/kg) |
| C0 | 717 ng/ml (single dose of 15 mg/kg) |
| γ | 2.50 |
| C50 | 665.4 ng/ml [m · 50.43 · (2)1/2.5]b |
Article of White (17).
Where m is equal to 10 and EC90 is equal to 50.43 ng/ml.
