Table 2.
Ontological analysis of common DEGs among COVID-19 and RA.
| Category | GO ID | Term | P-values | Genes |
|---|---|---|---|---|
| GO Biological Process | GO:0050870 | positive regulation of T cell activation | 1.65E-08 | RPS3/HLA-DPB1/HLA-DRA/HLA-DPA1/CD74/KLRK1/CD3E/LCK/IL7R/CCR7/CCL5 |
| GO:0050863 | regulation of T cell activation | 1.85E-08 | RPS3/HLA-DPB1/HLA-DRA/HLA-DPA1/CD74/KLRK1/CD3E/ARG1/LCK/IL7R/CCR7/CCL5/CLC | |
| GO:1903039 | positive regulation of leukocyte cell-cell adhesion | 4.55E-08 | RPS3/HLA-DPB1/HLA-DRA/HLA-DPA1/CD74/KLRK1/CD3E/LCK/IL7R/CCR7/CCL5 | |
| GO:0007159 | leukocyte cell-cell adhesion | 6.94E-08 | RPS3/S100A9/HLA-DPB1/HLA-DRA/HLA-DPA1/CD74/KLRK1/CD3E/ARG1/LCK/IL7R/CCR7/CCL5 | |
| GO:1903037 | regulation of leukocyte cell-cell adhesion | 1.78E-07 | RPS3/HLA-DPB1/HLA-DRA/HLA-DPA1/CD74/KLRK1/CD3E/ARG1/LCK/IL7R/CCR7/CCL5 | |
| GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide | 1.85E-07 | S100A9/S100A12/GNLY/CXCL9/PPBP/DEFA4/CAMP | |
| GO:0042110 | T cell activation | 2.03E-07 | RPS3/CD1C/HLA-DPB1/HLA-DRA/HLA-DPA1/CD74/KLRK1/CD3E/ARG1/LCK/IL7R/CCR7/CCL5/CLC | |
| GO:0022409 | positive regulation of cell-cell adhesion | 2.42E-07 | RPS3/HLA-DPB1/HLA-DRA/HLA-DPA1/CD74/KLRK1/CD3E/LCK/IL7R/CCR7/CCL5 | |
| GO:0042119 | neutrophil activation | 3.87E-07 | EEF1A1/TXNDC5/S100A9/QPCT/MMP9/S100A12/ANXA3/ARG1/TNFAIP6/TLR2/CCL5/PPBP/DEFA4/CAMP | |
| GO:0001906 | cell killing | 4.63E-07 | CD1C/HLA-DRA/S100A12/KLRK1/ARG1/IL7R/GNLY/DEFA4/CAMP | |
| GO Cellular Component | GO:0042613 | MHC class II protein complex | 1.40E-08 | HLA-DPB1/HLA-DRA/HLA-DPA1/HLA-DMA/CD74 |
| GO:0042611 | MHC protein complex | 1.64E-07 | HLA-DPB1/HLA-DRA/HLA-DPA1/HLA-DMA/CD74 | |
| GO:0030669 | clathrin-coated endocytic vesicle membrane | 1.68E-06 | HLA-DPB1/HLA-DRA/HLA-DPA1/FCGR1A/CD74 | |
| GO:0030666 | endocytic vesicle membrane | 2.08E-06 | HLA-DPB1/HLA-DRA/HLA-DPA1/FCGR1A/CD74/ANXA3/TLR2/MARCO | |
| GO:0030665 | clathrin-coated vesicle membrane | 2.51E-06 | HLA-DPB1/HLA-DRA/HLA-DPA1/FCGR1A/CD74/HIP1/IL7R | |
| GO:0034774 | secretory granule lumen | 6.61E-06 | EEF1A1/TXNDC5/S100A9/QPCT/S100A12/ARG1/CTSW/PPBP/DEFA4/CAMP | |
| GO:0030136 | clathrin-coated vesicle | 7.01E-06 | HLA-DPB1/HLA-DRA/HLA-DPA1/FCGR1A/CD74/HIP1/IL7R/SNX9 | |
| GO:0060205 | cytoplasmic vesicle lumen | 7.37E-06 | EEF1A1/TXNDC5/S100A9/QPCT/S100A12/ARG1/CTSW/PPBP/DEFA4/CAMP | |
| GO:0031983 | vesicle lumen | 7.78E-06 | EEF1A1/TXNDC5/S100A9/QPCT/S100A12/ARG1/CTSW/PPBP/DEFA4/CAMP | |
| GO:1904724 | tertiary granule lumen | 9.51E-06 | QPCT/MMP9/TNFAIP6/PPBP/CAMP | |
| GO Molecular Function | GO:0042608 | T cell receptor binding | 2.67E-05 | HLA-DRA/CD3E/LCK |
| GO:0023026 | MHC class II protein complex binding | 1.07E-04 | HLA-DRA/HLA-DMA/CD74 | |
| GO:0140375 | immune receptor activity | 1.12E-04 | HLA-DRA/HLA-DPA1/CD74/IL7R/CCR7/IL1R2 | |
| GO:0038187 | pattern recognition receptor activity | 2.73E-04 | TLR2/CLEC4E/MARCO | |
| GO:0033218 | amide binding | 3.32E-04 | CD1C/HLA-DPB1/HLA-DRA/HLA-DPA1/CD74/NQO2/TLR2/BDKRB1/MARCO | |
| GO:0042277 | peptide binding | 3.76E-04 | CD1C/HLA-DPB1/HLA-DRA/HLA-DPA1/CD74/TLR2/BDKRB1/MARCO | |
| GO:0023023 | MHC protein complex binding | 3.96E-04 | HLA-DRA/HLA-DMA/CD74 | |
| GO:0003735 | structural constituent of ribosome | 5.08E-04 | RPS3/RPL13A/RPL13/RPSA/RPL3/RPL18 | |
| GO:0042605 | peptide antigen binding | 7.37E-04 | HLA-DPB1/HLA-DRA/HLA-DPA1 | |
| GO:0032395 | MHC class II receptor activity | 1.34E-03 | HLA-DRA/HLA-DPA1 |
Top 10 terms of each category are listed.