TABLE 1.
Origin, drug susceptibility, and observed mutations of Enterococcus isolates chosen for sequencing
| Species | Strain | Animal origin | Yr of isolation | MIC (μg/ml) of:
|
Nucleotide (amino acid) substitutiona | |
|---|---|---|---|---|---|---|
| Avilamycin | Evernimicin | |||||
| E. faecalis | ATCC 19433 | 0.5 | 0.25 | — | ||
| ATCC 29212 | Human | 0.5 | 0.19 | — | ||
| 96-30477-4 | Pig | 1996 | 1 | 0.25 | — | |
| 96-31228-1 | Pig | 1996 | 0.5 | 0.5 | — | |
| 98-30756-2 | Pig | 1998 | 1 | 0.38 | — | |
| 98-30993-2 | Pig | 1998 | 1 | 0.125 | — | |
| 96-30354-3 | Pig | 1996 | >64 | 4 | CGT (Arg-56) → CAT (His-56) | |
| 96-30972-3 | Pig | 1996 | 32 | 2 | CGT (Arg-56) → CAT (His-56) | |
| 96-31097-2 | Pig | 1996 | >64 | 3 | CGT (Arg-56) → CAT (His-56) | |
| 96-31439-4 | Pig | 1996 | >64 | 6 | CGT (Arg-56) → CAT (His-56) | |
| 97-30100-4 | Pig | 1997 | >64 | 8 | CGT (Arg-56) → CAT (His-56) | |
| 97-30356-3 | Pig | 1997 | >64 | 8 | CGT (Arg-56) → CAT (His-56) | |
| 97-30477-2 | Pig | 1997 | >64 | 2 | CGT (Arg-56) → CAT (His-56) | |
| 97-30616-1 | Pig | 1997 | >64 | 3 | CGT (Arg-56) → CAT (His-56) | |
| 97-30729-5 | Pig | 1997 | >64 | 8 | CGT (Arg-56) → CAT (His-56) | |
| 97-31152-4 | Pig | 1997 | >64 | 4 | CGT (Arg-56) → CAT (His-56) | |
| 98-30352-2 | Pig | 1998 | >64 | 4 | CGT (Arg-56) → CAT (His-56) | |
| E. faecium | CCUG542 | Human | 1 | 0.5 | — | |
| 95-08111 | Broiler | 1995 | 0.5 | 0.5 | — | |
| 98-31068-1 | Broiler | 1998 | 2 | 0.19 | — | |
| 98-30182-1 | Pig | 1998 | 1 | 0.75 | — | |
| 98-30309-1 | Broiler | 1998 | 1 | 0.19 | — | |
| 98-31131 | Broiler | 1998 | 0.5 | 0.38 | — | |
| 98-31134 | Broiler | 1998 | 0.5 | 0.125 | — | |
| 95-08170 | Broiler | 1995 | >64 | 3 | ATC (Ile-52) → AGC (Ser-52) | |
| 95-08182 | Broiler | 1995 | >64 | 6 | ATC (Ile-52) → ACC (Thr-52) | |
| 96-08080 | Broiler | 1996 | >64 | 4 | ATC (Ile-52) → ACC (Thr-52) | |
| 96-31456-1 | Broiler | 1996 | >64 | 3 | CGT (Arg-56) → CAT (His-56) | |
| 97-30342-1 | Broiler | 1997 | >64 | 3 | CGT (Arg-56) → CAT (His-56) | |
| 97-31173-1 | Broiler | 1997 | >64 | 6 | ATC (Ile-52) → ACC (Thr-52) | |
| 98-30070-1 | Broiler | 1998 | >64 | 8 | ATC (Ile-52) → ACC (Thr-52) | |
| 98-30223-1 | Broiler | 1998 | >64 | 8 | CGT (Arg-56) → CAT (His-56) | |
| 98-30327-1 | Broiler | 1998 | >64 | 4 | CGT (Arg-56) → CAT (His-56) | |
| 98-31106-1 | Broiler | 1998 | >64 | 6 | CGT (Arg-56) → CAT (His-56) | |
| 98-31132 | Broiler | 1998 | 64 | 3 | ATC (Ile-52) → ACC (Thr-52) | |
a
—, no mutation (strain is susceptible to both drugs).