Table 5.
Selected examples of NMs targeting endothelial integrins.
| Targeting ligand | Carrier | Aim | Target | References |
|---|---|---|---|---|
| RGD | Various | Theranostic, inhibition of angiogenesis by blocking integrin function | αvβ3/ αvβ5 | Reviewed (155, 157, 158) |
| iRGD | Various | Imaging and image-guided phototherapy | αvβ3/ αvβ5 | Reviewed (161) |
| Antibody LM609 | Paramagnetic liposomal nanoparticles | Imaging | αvβ3 | (162) |
| Small molecule integrin αvβ3 inhibitor | Cationic lipid nanoparticles | Gene delivery | αvβ3 | (163) |
| Integrin αvβ3 binding compound (IA) | Lipid nanoparticles | Theranostic | αvβ3 | (164) |
| HSDVHK | Micelles | Inhibition of angiogenesis | αvβ5 | (165) |