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. 2022 Apr 7;13:848849. doi: 10.3389/fpsyt.2022.848849

Table 5.

Association between frailty and incident depressive symptoms not depressed at baseline.

Follow-up period Model 1
HR (95%CI)
Wald, df P-value Model 2
HR (95%CI)
Wald, df P-value Model 3
HR (95%CI)
Wald, df P-value Model 4
HR (95%CI)
Wald, df P-value
2011 → 2013 Frailty status
N = 839 Robust (471) Ref (1.000) Ref (1.000) Ref (1.000) Ref (1.000)
Pre-frail (343) 1.316
(0.959, 1.805)
2.9,1 0.089 1.366
(0.991, 1.882)
3.624,1 0.057 1.380
(0.957, 1.989)
2.972,1 0.085 1.395
(0.966, 2.013)
3.155,1 0.076
Frailty (25) 2.162
(0.945, 4.948)
3.332,1 0.068 2.207
(0.943, 5.168)
3.326,1 0.068 2.487
(0.948, 6.519)
3.431,1 0.064 2.458
(0.933, 6.479)
3.308,1 0.069
P-trend 1.366
(1.041, 1.793)
5.046,1 0.025 1.404
(1.064, 1.853)
5.756,1 0.016 1.443
(1.053, 1.978)
5.2,1 0.023 1.451
(1.057, 1.990)
5.316,1 0.021
2011 → 2015 Frailty status
N = 788 Robust (447) Ref (1.000) Ref (1.000) Ref (1.000) Ref (1.000)
Pre-frail (319) 1.386
(1.019, 1.885)
4.33,1 0.037 1.450
(1.06, 1.983)
5.417,1 0.020 1.400
(1.018, 1.923)
4.295,1 0.038 1.397
(1.017, 1.920)
4.249,1 0.039
Frailty (22) 2.492
(1.054,5.893)
4.326,1 0.038 2.939
(1.208, 7.153)
5.644,1 0.018 3.036
(1.231, 7.487)
5.815,1 0.016 2.992
(1.210, 7.397)
5.63,1 0.018
P-trend 1.443
(1.103, 1.886)
7.178,1 0.007 1.525
(1.159, 2.006)
9.08,1 0.003 1.494
(1.130, 1.976)
7.94,1 0.005 1.489
(1.126, 1.969)
7.775,1 0.005

Model 1, unadjusted; Model 2, adjusted for age, sex, educational levels, marital status, live place; Model 3, adjusted for age, sex, educational levels, marital status, live place, current smoking, alcohol drinking, activities, chronic diseases; Model 4, adjusted for age, sex, educational levels, marital status, live place, current smoking, alcohol drinking, activities, chronic diseases, BMI.