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. 2022 Apr 7;13:793582. doi: 10.3389/fimmu.2022.793582

Figure 4.

Figure 4

FBL inhibits the expression of ISGs in macrophages. (A) qRT-PCR analysis of Ldlr mRNA in mouse peritoneal macrophages transfected with the indicated siRNAs for 48 h (n=3); (B) Hotmap showing normalized transcript expression levels of immune-associated genes in WT and Fbl +/- RAW264.7 cells (n=3); (C) qRT-PCR analysis of Ifi44, Oas2, Ifit3, Ddx58, Ddx60, Oasl1, Bst2, Ifit1 mRNA in WT and Fbl +/- RAW264.7 cells (n=3); (D) qRT-PCR analysis of Ifi44, Oas2, Ifit3, Ddx58, Ddx60, Oasl1, Bst2, Ifit1 mRNA in mouse peritoneal macrophages transfected with the indicated siRNAs for 48 h (n=3). Data are mean ± SEM of biologically independent samples. ns, not significant, *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001, two-tailed unpaired Student’s t test.