Table 2.
Omeprazole PK parameters
| Control group (n = 24) |
Surgical group |
Comparison 1st month after surgery vs. baseline p (95% CI) | Comparison 6th month after surgery vs. baseline p (95% CI) | Comparison 6th month after surgery vs. control p (95% CI) | Comparison surgical group baseline vs. control group p (95% CI) | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| baseline (n = 14) |
1 month (n = 14 |
6 months (n = 13) |
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| mean ± SD | median | min | max | geometric mean | mean ± SD | median | min | max | geometric mean | mean ± SD | median | min | max | geometric mean | mean ± SD | median | min | max | geometric mean | |||||
| 1.8± 0.7 | 2.0 | 1.0 | 4.0 | 1.4± 0.5 | 1.1 | 1.0 | 2.0 | 1.8± 0.7 | 1.9 | 1.0 | 3.0 | 1.4±0.6 | 1.0 | 1 | 2.5 | 0.103 (−0.05 to −0.01) | 0.593 (−0.03 to 0.01) | 0.159 (−0.03 to −0.002) | 0.125 (−0.10 to 0.76) | |||||
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| Cmax, ng/mL | 515.9±386.2 | 443.5 | 118.1 | 1,892.6 | 411.6 | 749.3± 377.0 | 618.9 | 342.0 | 1,643.1 | 674.5 | 461.9± 365.7 | 309.1 | 26.2 | 1,229.0 | 318.3 | 486.1±348.5 | 359.2 | 20.4 | 1,154.3 | 343.5 | 0.001 (−429.6 to −145.2) | 0.003 (−466.0 to −123.0) | 0.819 (−231.6 to 291.0) | 0.078 (−4944 to 27.7) |
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| AUClast, h ng/mL | 1,458.9±1,518.7 | 876.6 | 228.0 | 7,060.8 | 977.6 | 2,053.8± 1,892.7 | 1,214.7 | 502.4 | 7,157.6 | 1,511.2 | 1,408.2± 1,820.1 | 636.3 | 50.3 | 6,730.9 | 688.3 | 1,327.0± 1,373.2 | 888.9 | 16.1 | 4,537.8 | 667.0 | <0.001 (−880.0 to −411.5) | 0.002 (−1,330.2 to −362.1) | 0.796 (−896.1 to 1,159.9) | 0.295 (−1,729.5 to 539.7) |
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| AUCinf, h ng/mL | 1,659.1±1,642.1 | 954.9 | 246.0 | 7,564.4 | 1,167.0 | 2,071.2± 1,902.7 | 1,226.3 | 503.5 | 7,181.5 | 1,523.7 | 1,680.4± 2,004.8 | 894.8 | 165.1 | 7,194.7 | 973.4 | 1,569.7± 1,393.7 | 1,072.9 | 268.1 | 4,599.2 | 1,073.3 | 0.001 (−900.0 to −300.0) | 0.008 (−1,248.9 to −236.2) | 0.878 (−1,090.3 to 1,269.0) | 0.495 (−1,625.4 to 801.2) |
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| t1/2, h | 1.3± 1.0 | 1.0 | 0.3 | 4.3 | 0.9± 0.6 | 0.8 | 0.3 | 2.3 | 0.9± 0.8 | 0.6 | 0.3 | 2.8 | 1.4± 1.2 | 1.0 | 0.3 | 4.7 | 0.495 (−0.4 to 0.2) | 0.384 [–0.5 to 1.3) | 0.871 (−0.9 to 0.8) | 0.178 [–0.2 to 1.0) | ||||
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| CI, mL/h | 0.0234± 0.0192 | 0.0209 | 0.00 | 0.08 | 0.02± 0.01 | 0.01 | 0.0 | 0.04 | 0.03± 0.03 | 0.03 | 0.0 | 0.1 | 0.03± 0.03 | 0.02 | 0 | 0.07 | 0.023 (0.0030-0.0033) | 0.056 (−0.0004 to 0.0264) | 0.616 (−0.198 to 0.0119) | 0.237 (−0.0046 to 0.0182) | ||||
Averages are presented as mean ± SD. SD, standard deviation.