Table 3.

Dose/weight-adjusted omeprazole pharmacokinetic parameters

	Control group (n = 24)	Surgical group (n = 14)			Comparison 1st month after surgery vs. baseline p (95% CI)	Comparison 6th month after surgery vs. baseline p (95% CI)	Comparison 6th month after surgery vs. control p (95% CI)	Comparison surgical group baseline vs. control group p (95% CI)
	mean ±SD	baseline mean ± SD	1 month mean ± SD	6 months mean ± SD
Cmax, ng/mL	515.9±386.2	749.3±377.0	461.9±365.7	486.1 ±348.5	0.001 (−429.6 to −145.2)	0.003 (−466.0 to −123.0)	0.819 (−231.6 to 291.0)	0.078 (−494.4 to 27.7)
AUClast, h ng/mL	1,458.9±1,518.7	2,053.8±1,892.7	1,408.2±1,820.1	1,327.0±1,373.2	<0.001 (−880.0 to −411.5)	0.002 (−1,330.2 to −362.1)	0.796 (−896.1 to 1,159.9)	0.295 (−1,729.5 to 539.7)
Cmax/(dose/weight)	2,059.34±1,479.78	4,340.81±2,554.31	2,279.60±1,852.20	2,042.34±1,514.49	<0.001 (−2,894.87 to −1,227.53)	<0.001 (−3,583.98 to −1,404.53)	0.974 (−1,025.91 to 1,059.9)	0.001 (−3,603.13 to −959.80)
AUClast/(dose/weight)	5,844.76±5,684.29	12,159.30±12,118.95	7,184.81 ±9,704.37	5,666.94±6,040.13	<0.001 (−6,819.17 to −3,129.8)	0.003 (−11,464.84 to −2,984.72)	0.930 (−3,883.11 to 4,238.74)	0.035 (−12168.95 to −460.14)
Dose/weight, mg/kg	0.18±0.05	0.15±0.02	0.21±0.03	0.25±0.04	<0.001 (0.02–0.04)	<0.001 (0.06–0.08)	0.788 (−0.03 to 0.04)	<0.001 (0.004–0.01)

Averages are presented as mean ± SD. SD, standard deviation.