TABLE 1.
Effects of hypoxia-ischemia on seizures in neonatal rats.
| No. pups total seizure | No. pups EGS | No. EGS | Total duration of EGS (min) | No. pups ECS | No. ECS | Total duration of ECS (min) | |
| Baseline (30 min) | 0/12 | 0/12 | — | — | 0/12 | — | — |
| After carotid ligation before hypoxia (30 min) | 5/12 | 5/12 | 2.2 ± 1.3 | 3.0 ± 2.2 | 1/12 | 5 | 13.1 |
| During HI (120 min) | 12/12 | 12/12 | 10.2 ± 12.5 | 4.0 ± 3.5 | 10/12 | 8.2 ± 6.7 | 8.2 ± 9.2 |
| Immediately after HI (30 min) | 10/12 | 10/12 | 2.9 ± 3.2 | 1.5 ± 2.0 | 8/12 | 1.3 ± 1.4 | 1.2 ± 2.1 |
| 24 h after HI (120 min) | 9/12 | 9/12 | 7.4 ± 8.0 | 8.0 ± 10.0 | 6/12 | 2.5 ± 1.6 | 9.0 ± 11.7 |
| 48 h after HI (120 min) | 7/12 | 5/12 | 4.3 ± 1.5 | 7.1 ± 1.7 | 7/12 | 4.2 ± 2.0 | 5.2 ± 2.7 |
| 72 h after HI (120 min) | 6/11 | 6/11 | 2.0 ± 1.4 | 3.3 ± 2.4 | 5/11 | 2.3 ± 1.0 | 8.2 ± 13.1 |
| 96 h after HI (120 min) | 4/11 | 4/11 | 1.3 ± 0.6 | 0.8 ± 0.5 | 0/11 | — | — |
| 120 h after HI (120 min) | 3/11 | 3/11 | 1.0 ± 0 | 0.5 ± 0.3 | 0/11 | — | — |
“No. pups total seizure” refers to the total number of seizures (including EGS and ECS) in rats recorded over a period of time. One rat died between 48 and 72 h after HI, and no other rat among 12 pups prepared died in this experiment. Data are shown as the mean values ± SD, n = 12.
HI, hypoxia–ischemia; EGS, electrographic seizure; ECS, electroclinical seizure.