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. 2022 Apr 7;12:855308. doi: 10.3389/fonc.2022.855308

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Copyright © 2022 Wang, Zhao, Song, Qiao, Di, Zhao, Sun, Zheng, Huang and Huang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptional expression of ERBB2d16 and ERBB2 in gastric cancer. (A) The schematic structure of the ERBB2d16 protein; (B) The transcriptional expression of ERBB2 and ERBB2d16 by quantitative RT-PCR in gastric cancer tissue with beta-actin as an internal control (n = 110); (C) The ratios of the ERBB2d16/ERBB2 in HER2-positive gastric cancer tissues (n = 110). (D) An ERBB2d16/ERBB2 ratio-dependent expression pattern of ERBB2d16 relative to ERBB2 expression. Δ16 low: ERBB2d16/ERBB2 ratio < 0.88; Δ16 high: ERBB2d16/ERBB2 ratio ≥ 0.88. ERBB2: human epidermal growth factor receptor-2; ERBB2d16: ERBB2ΔEx16; RT-PCR: reverse transcriptive polymerase chain reaction.