Skip to main content
. 2022 Apr 7;12:855308. doi: 10.3389/fonc.2022.855308

Figure 2.

Figure 2

Correlation of high ERBB2d16 expression with EMT-like phenotype. (A) Relative mRNA expression levels of E-cadherin (Ecad) and vimentin (Vim) in ERBB2d16 (Δ16) -low (n = 67) and -high (n = 43) groups, respectively. (B) The correlations between ERBB2 isoforms and EMT markers (E-cadherin and vimentin) by the Pearson’s correlation analysis (n = 110); (C, D). Hematoxylin and eosin (H&E) and immunofluorescent staining (E-cadherin and vimentin) of paired para-carcinoma tissue (C) and tumor tissues (D). Scale bar, 100 μm; (E). The expression of E-cadherin and vimentin, which was represented by the density of positive cells, in tumor tissue of low ERBB2d16 (n = 20), of high ERBB2d16 (n = 20), and paired para-carcinoma tissues (n = 40). (*p < 0.05, **p < 0.001, ***p < 0.0001, ****p < 0.00001), ns, not significant. Δ16 low: ERBB2d16/ERBB2 ratio < 0.88; Δ16 high: ERBB2d16/ERBB2 ratio ≥ 0.88. ERBB2: human epidermal growth factor receptor-2; ERBB2d16: ERBB2ΔEx16.