TABLE 2.
Screened differential metabolites.
| KEGG ID | Compound | RT (min) | m/z | VIP | p value | VIP | p value |
|---|---|---|---|---|---|---|---|
| (CON vs. CUMS) | (CON vs. CUMS) | (CUMS vs. ZZCD) | (CUMS vs. ZZCD) | ||||
| C00021 | S-Adenosyl-L-homocysteine | 0.97 | 385.1328 | 1.53 | 9.63E-10 | 1.56 | 3.01E-11 |
| C00047 | L-Lysine | 0.57 | 147.1141 | 1.04 | 1.73E-05 | 1.06 | 2.38E-05 |
| C00051 | Glutathione | 0.72 | 308.0959 | 1.33 | 1.91E-06 | 1.1 | 1.54E-05 |
| C00073 | L-Methionine | 0.74 | 150.0598 | 1.28 | 6.97E-07 | 1.21 | 3.46E-06 |
| C00078 | L-Tryptophan | 3.59 | 205.0984 | 1.34 | 2.99E-08 | 1.14 | 2.21E-05 |
| C00079 | L-Phenylalanine | 1.88 | 166.088 | 1.91 | 2.32E-09 | 1.77 | 1.50E-08 |
| C00121 | D-Ribose | 0.97 | 151.0644 | 1.6 | 1.64E-07 | 1.57 | 3.57E-08 |
| C00123 | L-Leucine | 1.14 | 132.1035 | 1.06 | 6.95E-05 | — | — |
| C00127 | Glutathione disulfide | 0.97 | 635.1502 | 1.3 | 9.28E-08 | 1.19 | 1.44E-06 |
| C00147 | Adenine | 1.12 | 136.0632 | 1.24 | 2.53E-06 | 1.7 | 4.11E-07 |
| C00242 | Guanine | 1.11 | 152.058 | 1.47 | 1.29E-06 | 1.87 | 3.33E-11 |
| C00294 | Inosine | 0.74 | 269.0908 | 1.05 | 1.50E-05 | 1.01 | 3.30E-04 |
| C00319 | Sphingosine | 13.18 | 322.2767 | 1.13 | 3.63E-05 | — | — |
| C00380 | Cytosine | 0.71 | 112.0515 | 1.38 | 3.63E-08 | 1.25 | 1.73E-05 |
| C00387 | Guanosine | 1.11 | 284.1021 | 1.48 | 2.44E-07 | 1.85 | 1.10E-08 |
| C00475 | Cytidine | 0.96 | 244.0953 | 1.28 | 3.87E-06 | 1.27 | 5.21E-06 |
| C00670 | sn-Glycero-3-phosphocholine | 0.7 | 258.1139 | 1.86 | 7.24E-10 | 2.02 | 9.29E-10 |
| C00791 | Creatinine | 0.69 | 114.0673 | — | — | 1.26 | 2.11E-05 |
| C00864 | Pantothenate | 2.44 | 220.1189 | 1.61 | 1.31E-07 | 1.45 | 2.37E-06 |
| C00956 | L-2-Aminoadipate | 0.73 | 162.0776 | 1.89 | 2.36E-10 | 1.78 | 6.37E-12 |
| C01419 | L-Cysteinyl-glycine | 0.96 | 179.0503 | 1.24 | 4.25E-06 | 1.41 | 3.28E-08 |
| C03758 | Dopamine | 0.97 | 154.0877 | 1.58 | 1.49E-07 | 1.69 | 2.60E-07 |
| C04230 | 2-Lysolecithin | 10.44 | 496.3483 | 2.06 | 1.85E-08 | 1.27 | 1.32E-05 |
| C05643 | 6-Hydroxymelatonin | 1.12 | 271.1026 | — | — | 1.01 | 3.53E-04 |
| C06999 | Fexofenadine | 10.14 | 502.3014 | 2.11 | 5.81E-10 | 1.73 | 9.87E-08 |
| C13856 | 2-Arachidonoylglycerol | 3.89 | 401.257 | 2.01 | 2.40E-09 | 2.03 | 2.92E-08 |