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. 2022 Apr 7;12:838152. doi: 10.3389/fonc.2022.838152

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Copyright © 2022 Ruan, Li, Du and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Survival analyses for hub genes. OS of the 10 down-regulated and 5 up-regulated hub genes was analyzed by Kaplan-Meier plotter. Data are presented as the hazard ratio with a 95% confidence interval. The log-rank P of the down-regulated hub genes ESR1 (A), AR (B), FOS (C), CYP1A1 (D), CYP3A4 (E), CYP1A2 (F), CYP2B6 (G), ABCG2 (H), HMDX1 (I) and CCL2 (J) were 0.005, 0.022, 0.62, 0.57, 0.05, 0.36, 0.25, 0.84, 0.12 and 0.68. The log-rank P of the up-regulated hub genes CCNB1 (K), CDK1 (L), NQO1 (M), AKR1C3 (N) and CCNA2 (O) were 1.1e-06, 3.9e-05, 0.12, 0.0037 and 4.4e-05. Log-rank P < 0.05 was regarded as statistically significant.