TABLE 1.
PD50s of telithromycin and other antibiotics for enterococci in the mouse peritonitis model
| Antibiotic | Route of therapyb | PD50 (mg/kg) fora:
|
||||||
|---|---|---|---|---|---|---|---|---|
|
E. faecalis
|
E. faecium
|
|||||||
| OG1RF (ATCC 47077) | TX0921 Bla+ Chli Genr Tetr | TX0052 Chli Eryr [erm(B)] Genr Strr | V583 Chli Eryr [erm(B)] Tetr Vanr (vanB) | TX16 Chli Eryr [erm(B)] Genr Strr Tetr | TX16.01-Eryc Genr Strr Tetr | TX2465 Ampr Chli Eryi Vanr (vanA) | ||
| TEL | 0.031 | 0.015 | 4–8 | 8 | 16 | 0.062 | 0.015–0.031 | |
| p.o., 1 dose | 29.7 | 34.9 | >200 | >200 | >200 | 12.5 | 38.6 | |
| p.o., 2 doses | — | — | 80 | >200 | 168 | 9.35 | — | |
| s.c., 1 dose | 9.4 | 0.57 | >50 | >50 | >50 | 13.6 | 10.4 | |
| s.c., 2 doses | — | — | 40 | 25 | 12.5 | 3.12 | — | |
| ERY | 0.5 | 0.5 | 1,024 | 512–1,024 | 1,024 | 2 | 2–4 | |
| p.o., 1 dose | >200 | >200 | >200 | — | >200 | >200 | — | |
| s.c., 1 dose | 31.9 | 12.5 | >200 | >200 | >200 | 27.7 | 35.6 | |
| Q-D | 8 | 8 | 16 | 16 | 1 | 1 | 1 | |
| s.c., 1 dose | — | — | — | — | >200 | 27.9 | — | |
| s.c., 2 doses | — | — | — | — | 36.5 | — | — | |
| i.v., 1 dose | — | — | — | — | 32.1 | 15.2 | 10.2 | |
a
Values in bold are MICs, (in micrograms per milliliter). Ranges represent the results of different determinations. Chl, chloramphenicol; Str, streptomycin; Tet, tetracycline; Van, vancomycin. MICs were 1 to 4 μg/ml for Eryi and 16 μg/ml for Chli. —, not tested.
b
Single-dose administration of drug was performed at 0 h immediately after intraperitoneal inoculation of bacteria. Two-dose administration was performed at 0 and 4 h after infection.