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. Author manuscript; available in PMC: 2022 Apr 21.
Published in final edited form as: ACS Chem Neurosci. 2021 Jan 25;12(3):517–530. doi: 10.1021/acschemneuro.0c00737

Figure 3.

Figure 3.

One-step approach for the synthesis of [18F]PS13 including precursor 5 synthesis. Reagents and conditions: (i) 4-methoxybenzoyl chloride, toluene, pyrimidine, 110 °C, 2.5 h; (ii) KOH (10%, aq.), EtOH, 60 °C, 1.5 h; (iii) 1. K2CO3, DMF, RT, 10 min and 2. 1,1,1-trifluoro-2-iodoethane, 100 °C, 3 h; (iv) n-BuLi (1.6 M in hexanes), THF, −78 °C, 45 min; (v) [18F]F−, K 2.2.2, K2CO3, DMSO, proton source, thermal heating, 10–20 min.