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. Author manuscript; available in PMC: 2022 Apr 21.
Published in final edited form as: ACS Chem Neurosci. 2021 Jan 25;12(3):517–530. doi: 10.1021/acschemneuro.0c00737

Table 1.

Conditions Screening for the Synthesis of [18F]PS13 via the One-Step Approach

entrya temp (°C) time (min) proton source proton source (μL)b yield ratio of [18F]PS13 to [18F]5c yield of [18F]PS13c (%) Am of [18F]PS13d (GBq/μmol)
1 90 20 IPA 10.8 1:5
2e 90 20 IPA 21.6 1:2.5
3 90 20 tert-BuOH 21.6 1:5
4 130 20 IPA 21.6 1:2
5 130 (MW) 20 IPA 21.6 1:2.5
6 130 2 (NH4)2CO3(aq.) 1.6 1:5
7f 130 20 NH4Cl(aq.) 1.6 1:0.9 0.8 14.2
8e 130 20 NH4Cl(aq.) 3.2 1:0.4 3.3 16.8
9 130 20 NH4Cl(aq.) 6.4 1:0.4 0.8 8.6
10 130 20 NH4Cl(aq.) 16 0:0 0
11 130 (MW) 2 NH4Cl(aq.) 1.6 1:10
12g 130 20 IPA 21.6 5.9 0.6
13g 130 10 IPA 21.6 4.5 1.0
a

Reactions (n = 1) were performed with 5 (1.5 mg) in DMSO (300 μL), unless otherwise noted.

b

Volume per reaction.

c

Yield ratios and yields were determined from radiochromatograms acquired during HPLC analysis of the crude reaction mixture.

d

Decay-corrected to ERP.

e

n = 2.

f

n = 4.

g

Reaction used 3 mg of precursor 5.