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. Author manuscript; available in PMC: 2022 Apr 21.
Published in final edited form as: ACS Chem Neurosci. 2021 Jan 25;12(3):517–530. doi: 10.1021/acschemneuro.0c00737

Table 2.

Time Study for Step 1 (Two-Step Approach) with IPA as a Proton Source

entrya time (min) [18F]6 yield (%)b Am of [18F]6 (GBq/μmol)c
1 1 54 1.3
2 2.5 56 0.8
3 5 61 0.4
4 10 63 0.3
a

Reactions (n = 1) were performed with 2,2-difluorovinyl 4-methylbenzenesulfonate (2.5 mg) and IPA (38 μL) in DMSO (500 μL) at 85 °C.

b

Yields were determined from radiochromatograms acquired during HPLC analysis of the crude reaction mixture.

c

Decay-corrected to ERP.