TABLE 1.
Outcome of therapy of chronic osteomyelitis due to S. aureusa
| Antimicrobial therapy | No. of animals | Median log10 CFU/g of bone | Range (25th–75th percentile) |
|---|---|---|---|
| None | 16 | 5.09 | 4.59–5.49 |
| Linezolid b.i.d. | 16 | 5.32 | 4.54–5.75 |
| Linezolid t.i.d. | 13 | 4.90 | 3.03–5.70 |
| Cefazolin | 15 | 3.78 | 2.81–4.36 |
a
Linezolid dosed b.i.d, was not significantly different than no treatment; linezolid dosed t.i.d. was not significantly different than no treatment or cefazolin. Cefazolin was more active (P = 0.001) than no treatment or linezolid dosed b.i.d.