TABLE 2.
Concentrations of antimicrobials in serum during experimental infection
| Drug, dose, and route | Concn in serum (μg/ml) at:
|
AUC0–8 (μg · h/ml) | |||||
|---|---|---|---|---|---|---|---|
| 0.5 h | 1 h | 2 h | 4 h | 6 h | 8 h | ||
| Linezolid, 25 mg/kg, i.p.a | 32.0 ± 1.5 | 18.5 ± 4.1 | 8.7 ± 2.5 | 5.8 ± 0.5 | 4.4 ± 0.6 | <1 ± 0.01 | —d |
| Linezolid, 25 mg/kg, i.p.b | 16.5 ± 6.2 | 21.4 ± 4.2 | 11.7 ± 1.0 | 7.6 ± 0.6 | 3.7 ± 3.0 | 1.1 ± 0.6 | 61.5 |
| Cefazolin, 50 mg/kg, i.m.c | 163 ± 15.5 | 82.5 ± 9.5 | 14.9 ± 5.7 | <5 ± 0.01 | <5 ± 0.01 | <5 ± 0.01 | 110 |
a
Mean concentration in serum among three healthy rats after a single dose of linezolid.
b
Mean concentration in serum among three infected rats at steady state after 6 days of linezolid administered t.i.d.
c
Mean concentration in serum among three infected rats at steady state after 5 days of cefazolin administered t.i.d. intramuscularly (i.m.).
d
For a single dose of linezolid, 25 mg/kg, i.p., the AUC0–6 was 52.5 μg · h/ml.