TABLE 4.

Univariate and multivariate analyses of different clinical characteristics in TCGA cohort and GEO cohort.

TCGA	Univariate Cox analysis				Multivariate Cox regression
—	HR	HR.95L	HR.95H	p-value	HR	HR.95L	HR.95H	p-value
Age	1.034	1.019	1.048	<0.001	1.035	1.020	1.050	<0.001
M	6.414	3.604	11.415	<0.001	1.429	0.630	3.240	0.392
N	1.649	1.377	1.975	<0.001	1.187	0.892	1.579	0.239
T	1.570	1.270	1.942	<0.001	1.016	0.756	1.364	0.917
Stage	2.131	1.690	2.687	<0.001	1.616	0.973	2.684	0.064
Risk score	2.691	1.387	5.222	0.003	2.025	1.023	4.009	0.043
GEO	Univariate Cox analysis				Multivariate Cox regression
—	HR	HR.95L	HR.95H	p-value	HR	HR.95L	HR.95H	p-value
Age	0.992	0.971	1.014	0.483	1.003	0.983	1.024	0.759
T	1.863	1.440	2.412	<0.001	1.318	0.925	1.880	0.127
N	1.757	1.448	2.134	<0.001	1.665	1.338	2.072	<0.001
M	5.204	2.391	11.326	<0.001	1.367	0.496	3.770	0.546
Risk score	2.713	1.148	6.410	0.023	3.554	1.389	9.092	0.008

HR, hazard ratio.