TABLE 5.
DEGs between the low- and high-risk groups in the TCGA cohort.
| Gene | Low mean | High mean | logFC | FDR |
|---|---|---|---|---|
| CORO1A | 5.360104747 | 4.039533552 | −1.320571195 | 1.4533E-102 |
| ICOS | 2.66870652 | 1.401707634 | −1.266998885 | 6.0567E-99 |
| ADAMDEC1 | 4.067634374 | 2.677191427 | −1.390442946 | 1.58179E-61 |
| UBASH3A | 2.396795426 | 1.235868978 | −1.160926447 | 4.8647E-113 |
| SLPI | 6.417742723 | 5.374261184 | −1.043481539 | 2.82123E-15 |
| IL2RG | 5.381610354 | 3.590786963 | −1.790823392 | 6.3889E-123 |
| LTB | 4.162616237 | 2.693823165 | −1.468793072 | 1.12041E-83 |
| KLHDC7B | 3.641745108 | 2.602829947 | −1.03891516 | 4.84572E-44 |
| CD6 | 2.907802118 | 1.86808555 | −1.039716568 | 2.6307E-108 |
| GZMA | 4.924957952 | 3.098356833 | −1.826601119 | 6.4323E-129 |
| CD247 | 3.313011386 | 2.175286145 | −1.137725241 | 2.4537E-114 |
| GBP4 | 4.608669232 | 3.234306381 | −1.374362851 | 8.51808E-87 |
| CYBB | 4.794343167 | 3.677356315 | −1.116986852 | 2.25184E-71 |
| ZAP70 | 3.006312166 | 1.979412401 | −1.026899765 | 4.3563E-100 |
| LGALS9 | 5.115470076 | 4.114339016 | −1.00113106 | 4.46913E-83 |
| CCL18 | 3.924514642 | 2.60205151 | −1.322463132 | 2.78856E-41 |
| SLAMF8 | 4.366530125 | 3.086536589 | −1.279993536 | 5.46533E-90 |
| EEF1A2 | 4.563524061 | 5.738800508 | 1.175276447 | 7.28811E-16 |
| GBP1P1 | 2.449571975 | 1.27318215 | −1.176389825 | 2.69048E-88 |
| IDO1 | 4.011478175 | 2.390257247 | −1.621220928 | 1.22696E-94 |
| APOE | 8.128534974 | 7.095641377 | −1.032893598 | 3.36347E-46 |
| SPI1 | 4.725939757 | 3.587575922 | −1.138363835 | 1.42452E-90 |
| CPB1 | 2.939800849 | 4.193458095 | 1.253657245 | 3.63074E-08 |
| CCL4 | 4.115440664 | 3.03068862 | −1.084752045 | 3.2697E-93 |
| C1S | 7.307363861 | 6.222951045 | −1.084412816 | 1.03439E-52 |
| PTGDS | 4.923081328 | 3.531880381 | −1.391200948 | 1.16044E-55 |
| RAC2 | 5.72871771 | 4.525700365 | −1.203017345 | 3.91066E-91 |
| IGHD | 3.051991654 | 2.02802661 | −1.023965043 | 4.26743E-34 |
| BIN2 | 3.709266834 | 2.559470948 | −1.149795886 | 2.8028E-109 |
| CCR5 | 4.284251105 | 2.993071484 | −1.291179621 | 1.0578E-116 |
| GPR171 | 2.881081182 | 1.79534601 | −1.085735173 | 6.2069E-100 |
| S1PR4 | 2.787226885 | 1.7424426 | −1.044784285 | 3.5729E-100 |
| AOAH | 3.513732239 | 2.494757235 | −1.018975004 | 3.01337E-95 |
| CST7 | 4.595045167 | 3.165546127 | −1.42949904 | 8.5695E-104 |
| HLA-DPB1 | 7.642577226 | 6.371570292 | −1.271006934 | 9.7664E-101 |
| TNFRSF17 | 2.95989884 | 1.840601865 | −1.119296975 | 2.05885E-53 |
| HCP5 | 5.290979401 | 4.240242684 | −1.050736717 | 6.1271E-58 |
| CD3E | 4.527286876 | 2.861578069 | −1.665708807 | 5.2271E-116 |
| SPOCK2 | 4.154981604 | 2.896084803 | −1.258896802 | 4.43455E-95 |
| SELPLG | 5.040260081 | 3.923229581 | −1.1170305 | 5.03095E-93 |
| NKG7 | 4.733281588 | 2.848564769 | −1.884716819 | 2.8775E-122 |
| S100A8 | 4.508000675 | 3.100904178 | −1.407096498 | 3.4299E-31 |
| LTF | 7.30144272 | 5.734845084 | −1.566597636 | 6.46878E-19 |
| CARD16 | 3.450089988 | 2.437280475 | −1.012809513 | 1.9148E-110 |
| IGLV1-44 | 6.246509235 | 4.17187417 | −2.074635065 | 1.66624E-49 |
| IGHG1 | 7.350130441 | 4.929048971 | −2.42108147 | 3.76055E-51 |
| S100A9 | 6.939100023 | 5.333109776 | −1.605990247 | 7.49594E-29 |
| GZMB | 3.70949304 | 2.070526724 | −1.638966316 | 1.5122E-101 |
| HLA-DRA | 10.56132681 | 9.157501678 | −1.403825133 | 7.2754E-108 |
| S100A7 | 4.069054754 | 2.809805452 | −1.259249301 | 1.11916E-12 |
| CD79A | 4.366519802 | 2.713664675 | −1.652855127 | 6.25078E-67 |
| FDCSP | 4.642483781 | 2.985719615 | −1.656764166 | 1.28725E-27 |
| IGHV1-69 | 3.315959777 | 1.963011155 | −1.352948622 | 3.55083E-37 |
| HLA-DPA1 | 7.39906434 | 6.063546257 | −1.335518083 | 1.13415E-93 |
| TNFRSF1B | 5.181175125 | 4.097575956 | −1.083599169 | 7.1194E-103 |
| TRAC | 5.783767342 | 4.117421753 | −1.666345589 | 1.2437E-105 |
| ACKR1 | 4.484716745 | 3.392594695 | −1.09212205 | 8.43227E-23 |
| SELL | 4.700846275 | 3.272053084 | −1.428793192 | 1.31627E-82 |
| GZMM | 3.05536066 | 1.892536439 | −1.162824222 | 7.4963E-92 |
| LCK | 3.944866286 | 2.52912373 | −1.415742556 | 1.7523E-110 |
| HLA-DQA1 | 6.247503546 | 4.076673578 | −2.170829968 | 3.76188E-89 |
| CXCL10 | 6.975795807 | 4.976685426 | −1.999110381 | 1.686E-81 |
| SIT1 | 3.28843416 | 1.882746759 | −1.405687401 | 9.2293E-112 |
| PRF1 | 3.668183558 | 2.442155392 | −1.226028166 | 1.4193E-115 |
| C1QC | 7.845681197 | 6.675610114 | −1.170071082 | 1.0383E-82 |
| LAG3 | 3.106890931 | 2.086277781 | −1.020613151 | 1.79066E-80 |
| CCL2 | 5.46286324 | 4.337065426 | −1.125797814 | 4.88778E-61 |
| APOL1 | 6.050047347 | 4.908171095 | −1.141876252 | 3.70502E-84 |
| IL18 | 4.190789992 | 3.044475659 | −1.146314333 | 9.6008E-126 |
| HLA-F | 6.106118877 | 4.956620172 | −1.149498705 | 1.21661E-79 |
| CTSW | 3.397907205 | 1.869805587 | −1.528101618 | 5.75927E-97 |
| RARRES1 | 5.269708166 | 3.950770119 | −1.318938047 | 5.39529E-42 |
| IGKC | 8.658650476 | 6.398117726 | −2.26053275 | 1.0066E-54 |
| LAMP3 | 3.99196859 | 2.679670854 | −1.312297736 | 1.17868E-77 |
| BCL2A1 | 3.920467154 | 2.715766402 | −1.204700753 | 1.7772E-80 |
| CD79B | 3.002966686 | 2.001833894 | −1.001132793 | 7.4998E-68 |
| FERMT3 | 4.761586406 | 3.581359542 | −1.180226864 | 1.5344E-99 |
| IGHM | 7.383651483 | 5.072475929 | −2.311175554 | 6.47352E-53 |
| IL2RB | 4.231582771 | 3.018756424 | −1.212826348 | 1.42754E-92 |
| CXCL9 | 6.821303571 | 4.359150742 | −2.462152829 | 2.06771E-90 |
| C1QB | 7.515156442 | 6.219815826 | −1.295340615 | 4.79414E-89 |
| NAPSB | 4.233310224 | 3.091702908 | −1.141607316 | 9.82202E-68 |
| SIRPG | 2.47922886 | 1.374519633 | −1.104709228 | 1.4276E-113 |
| IL32 | 5.59450272 | 4.310250032 | −1.284252687 | 4.138E-78 |
| SASH3 | 4.761827311 | 3.529669244 | −1.232158067 | 4.8384E-116 |
| TIGIT | 3.018274307 | 1.869993222 | −1.148281086 | 6.3794E-108 |
| MS4A1 | 3.090610318 | 1.892911125 | −1.197699193 | 5.40303E-69 |
| CASP1 | 4.613143497 | 3.599216242 | −1.013927256 | 1.9168E-100 |
| CD7 | 3.141448175 | 1.968091019 | −1.173357157 | 9.1813E-106 |
| CXCR6 | 2.827605632 | 1.795738331 | −1.031867301 | 3.9044E-108 |
| HCST | 4.46600762 | 3.295520384 | −1.170487236 | 1.52549E-96 |
| EBI3 | 3.018209859 | 1.925793352 | −1.092416507 | 3.48739E-86 |
| IL7R | 4.438791573 | 3.031530025 | −1.407261549 | 8.37936E-83 |
| SLAMF7 | 3.839990058 | 2.377133193 | −1.462856865 | 4.71716E-96 |
| IRF8 | 4.377807761 | 3.327696457 | −1.050111305 | 4.67308E-92 |
| HLA-DQB1 | 5.839998886 | 4.356166276 | −1.483832611 | 7.66425E-80 |
| HLA-DMB | 5.547993757 | 4.360576097 | −1.18741766 | 2.0215E-108 |
| EVI2B | 5.153593436 | 3.938844092 | −1.214749344 | 1.39392E-98 |
| SPN | 2.631629192 | 1.615489013 | −1.016140178 | 1.73311E-97 |
| HLA-DMA | 6.717204277 | 5.498473069 | −1.218731209 | 4.0656E-113 |
| TAP1 | 6.638832453 | 5.48554722 | −1.153285233 | 5.03798E-65 |
| PLA2G2D | 2.400055862 | 0.99788987 | −1.402165992 | 6.14283E-83 |
| CYTIP | 4.182375059 | 3.049161213 | −1.133213846 | 2.2841E-87 |
| CXCL13 | 5.554707054 | 3.423637016 | −2.131070037 | 1.90005E-64 |
| CLEC10A | 3.141723147 | 2.071571778 | −1.070151369 | 4.2604E-67 |
| WAS | 4.161853167 | 3.138125438 | −1.023727729 | 2.2478E-113 |
| HLA-DQB2 | 4.483645366 | 3.346969498 | −1.136675869 | 5.5854E-58 |
| CD3G | 2.782069722 | 1.633347888 | −1.148721835 | 3.0213E-106 |
| IL10RA | 4.492164569 | 3.373913704 | −1.118250865 | 2.8396E-102 |
| HCLS1 | 5.365722359 | 4.240379245 | −1.125343114 | 3.8519E-104 |
| CCL21 | 4.486810762 | 3.239732148 | −1.247078614 | 1.88152E-29 |
| FPR3 | 4.942062247 | 3.926922957 | −1.015139291 | 1.50175E-51 |
| SRGN | 7.136395383 | 5.906759073 | −1.22963631 | 1.31748E-95 |
| GPR183 | 4.741687685 | 3.523698318 | −1.217989367 | 2.08636E-75 |
| MAP4K1 | 3.200923701 | 2.039054283 | −1.161869419 | 1.046E-102 |
| CD5 | 3.367912498 | 2.097936429 | −1.269976068 | 4.6643E-107 |
| CD53 | 5.610501937 | 4.295049786 | −1.315452152 | 3.241E-111 |
| HLA-DOA | 4.210149047 | 3.164637444 | −1.045511603 | 1.03338E-83 |
| CD3D | 4.941889641 | 3.141417665 | −1.800471975 | 6.9829E-123 |
| GNLY | 3.208806672 | 1.934835347 | −1.273971325 | 7.82857E-97 |
| GBP5 | 3.888090151 | 2.392565378 | −1.495524773 | 5.19835E-98 |
| CXCL11 | 4.77682554 | 3.035835962 | −1.740989578 | 1.85212E-78 |
| BIRC3 | 4.341237451 | 3.190572681 | −1.150664769 | 2.20649E-78 |
| C16orf54 | 3.415507471 | 2.285109419 | −1.130398052 | 2.473E-103 |
| CD69 | 3.663594833 | 2.634742101 | −1.028852731 | 4.16642E-80 |
| C1QA | 7.688633915 | 6.330589492 | −1.358044423 | 2.98309E-92 |
| DOK2 | 3.688886573 | 2.617313807 | −1.071572767 | 1.35046E-95 |
| CD48 | 4.344626171 | 2.991797311 | −1.35282886 | 1.8574E-117 |
| FGL2 | 5.113359749 | 3.994426038 | −1.118933711 | 1.55171E-76 |
| TRAV12-2 | 2.127961852 | 1.03905828 | −1.088903573 | 2.2292E-93 |
| GIMAP4 | 5.464517511 | 4.410288234 | −1.054229277 | 1.84947E-93 |
| GBP1 | 5.840635431 | 4.424450267 | −1.416185164 | 5.68627E-84 |
| TRAT1 | 2.500318227 | 1.450122923 | −1.050195304 | 3.3268E-104 |
| C3 | 7.838554587 | 6.53817962 | −1.300374968 | 1.50441E-66 |
| CD37 | 3.979895154 | 2.860805383 | −1.119089771 | 5.0979E-105 |
| IGLL5 | 5.626926768 | 3.830681897 | −1.796244871 | 2.14691E-51 |
| IGLV6-57 | 4.440534612 | 2.603583196 | −1.836951416 | 1.35126E-44 |
| CCL8 | 4.013560591 | 2.961382408 | −1.052178183 | 1.42265E-51 |
| TYROBP | 7.265365441 | 6.236943531 | −1.028421911 | 3.18142E-82 |
| FCER1G | 6.731394543 | 5.710139026 | −1.021255517 | 3.01917E-84 |
| CD8A | 4.139211436 | 2.692320927 | −1.44689051 | 3.1195E-104 |
| KLRB1 | 3.224712682 | 2.122700348 | −1.102012334 | 6.13308E-89 |
| CD27 | 4.109424689 | 2.714609904 | −1.394814785 | 2.27118E-97 |
| MMP7 | 5.712559584 | 4.574873337 | −1.137686247 | 1.43786E-22 |
| CD52 | 6.214804266 | 4.389171799 | −1.825632467 | 2.4335E-105 |
| APOC1 | 7.08329022 | 6.015604239 | −1.067685981 | 6.72133E-52 |
| GIMAP7 | 5.057493352 | 3.934627555 | −1.122865798 | 2.75875E-78 |
| CXCR3 | 3.322254993 | 1.927552465 | −1.394702528 | 7.9032E-116 |
| PLEK | 4.988885801 | 3.71449876 | −1.274387041 | 2.661E-99 |
| CCR7 | 3.766279493 | 2.452475926 | −1.313803567 | 2.67691E-90 |
| GMFG | 5.171020452 | 4.120109114 | −1.050911339 | 4.5574E-101 |
| CD2 | 5.421111687 | 3.538445918 | −1.882665769 | 1.8373E-123 |
| CD96 | 2.855881742 | 1.696207766 | −1.159673976 | 5.8805E-111 |
| TMC8 | 3.47037334 | 2.442798459 | −1.027574881 | 1.1318E-108 |
| HLA-B | 10.5049036 | 9.455108846 | −1.049794758 | 2.70117E-74 |
| LYZ | 7.517179112 | 5.747192503 | −1.76998661 | 5.72105E-71 |
| SLAMF6 | 3.41444143 | 2.202687773 | −1.211753656 | 4.5438E-107 |
| CHI3L1 | 5.21416871 | 4.140128252 | −1.074040459 | 5.67107E-26 |
| LGALS2 | 3.404502369 | 2.038701675 | −1.365800694 | 1.60395E-76 |
| ITGB2 | 5.286587731 | 4.082371297 | −1.204216433 | 1.02151E-83 |
| PTPRC | 4.462383664 | 3.114560617 | −1.347823047 | 2.42856E-89 |
| GZMK | 4.219947755 | 2.510364693 | −1.709583061 | 3.1821E-105 |
| CSF2RB | 4.130809361 | 3.110874429 | −1.019934932 | 4.88547E-79 |
| IL4I1 | 3.931211922 | 2.677897202 | −1.25331472 | 8.04983E-70 |
| GZMH | 3.385255319 | 1.994160798 | −1.391094521 | 5.0674E-107 |
| CCL19 | 5.997614042 | 3.970147578 | −2.027466464 | 8.17781E-60 |
| HLA-DOB | 3.132584238 | 2.056886162 | −1.075698075 | 2.7306E-84 |
| SH2D1A | 2.744864409 | 1.567963027 | −1.176901382 | 4.9839E-110 |
| CD38 | 2.881080346 | 1.829525409 | −1.051554937 | 2.93629E-86 |
| MPEG1 | 5.038123971 | 3.940072182 | −1.098051789 | 1.1602E-76 |
| CD4 | 4.726462006 | 3.613613486 | −1.11284852 | 1.2146E-102 |
| HLA-DRB6 | 5.062636453 | 3.814124126 | −1.248512327 | 2.05324E-71 |
| PSMB9 | 5.736704054 | 4.411715021 | −1.324989032 | 1.83162E-95 |
| IRF1 | 5.078369975 | 4.069631847 | −1.008738129 | 1.8158E-107 |
| CD74 | 9.735425117 | 8.383650479 | −1.351774638 | 3.9705E-115 |
| LAPTM5 | 7.783373879 | 6.703807082 | −1.079566797 | 4.65831E-94 |
| CTSS | 6.315416511 | 5.053186817 | −1.262229694 | 2.2885E-96 |
| AIF1 | 5.469002536 | 4.38958142 | −1.079421115 | 2.505E-103 |
| CCL5 | 6.565983508 | 4.546408762 | −2.019574746 | 3.34E-120 |