Table 2.
Hazard ratios for each cancer components.
| Events | Person-year | Hazard ratio (95% CI) | ||
|---|---|---|---|---|
| Unadjusted | Adjusted | |||
| All Cancer | ||||
| Non-users | 11369 | 520292 | – | – |
| LTRAs | 10399 | 536725 | 0.88 (0.86 – 0.91) | 0.85 (0.83 – 0.87) |
| Lung Cancer | ||||
| Non-users | 989 | 551209 | – | – |
| LTRAs | 1201 | 560047 | 1.19 (1.09 – 1.29) | 1.06 (0.94 – 1.16) |
| Liver Cancer | ||||
| Non-users | 1681 | 548448 | – | – |
| LTRAs | 1271 | 559331 | 0.74 (0.69 – 0.79) | 0.73 (0.68 – 0.79) |
| Colorectal Cancer | ||||
| Non-users | 1133 | 550157 | – | – |
| LTRAs | 1017 | 559934 | 0.88 (0.81 – 0.96) | 0.83 (0.76 – 0.91) |
| Stomach Cancer | ||||
| Non-users | 819 | 551045 | – | – |
| LTRAs | 625 | 560859 | 0.75 (0.67 – 0.83) | 0.69 (0.62 – 0.76) |
| Pancreas Cancer | ||||
| Non-users | 672 | 551969 | – | – |
| LTRAs | 641 | 561173 | 0.93 (0.84 – 1.04) | 0.91 (0.81 – 1.01) |
| Breast Cancer | ||||
| Non-users | 1433 | 549177 | – | – |
| LTRAs | 1181 | 559698 | 0.80 (0.74 – 0.87) | 0.77 (0.71 – 0.83) |
| Urological Cancer | ||||
| Non-users | 2146 | 547338 | – | – |
| LTRAs | 2191 | 557066 | 1.00 (0.94 – 1.06) | 0.92 (0.86 – 0.97) |
| Skin Cancer | ||||
| Non-users | 516 | 550132 | – | – |
| LTRAs | 534 | 558712 | 1.02 (0.90 – 1.15) | 1.00 (0.88 – 1.14) |
| Brain and Central Nervous System Cancer | ||||
| Non-users | 175 | 548347 | – | – |
| LTRAs | 150 | 554163 | 0.85 (0.68 – 1.05) | 0.83 (0.67 – 1.03) |
Hazard ratio was adjusted for age at enrollment, sex, index year, region, economic status, concomitant asthma/anti-allergy medications, initial diagnosis, charlson comorbidity index, smoking status, alcohol intake, and body mass index. CI, confidence interval; LTRAs, Cysteinyl leukotrienes receptor antagonist.