Figure 5.

Summary of the epitope mapping results. HLA class II restriction and minimal core amino acids recognized by the clones analyzed in this study are aligned above the proinsulin sequence. Previously reported T-cell epitopes recognized by human T cells isolated from blood, pancreatic islets or pancreatic lymph nodes of patients with T1D are aligned below the proinsulin sequence. The original publications reporting these epitopes are indicated in parentheses after the minimal core sequence. Epitopes with a black frame have been demonstrated to be naturally processed from proinsulin protein.