Table III.
TCR sequences of the proinsulin-specific T-cell clones.
| Clone | TRBV | TRBJ | TRB CDR3 | TRB CDR3 length | TRAV | TRAJ | TRA CDR3 | TRA CDR3 length |
|---|---|---|---|---|---|---|---|---|
| 1 | TRBV14 | TRBJ2-7 | CASSQALAGVAEQYF | 15 | TRAV41 | TRAJ49 | CAASNTGNQFYF | 12 |
| 2 | TRBV6-1 | TRBJ1-2 | CASSMTQGLDYGYTF | 15 | TRAV13-1 | TRAJ17 | CAASSKAAGNKLTF | 14 |
| 3 | TRBV9 | TRBJ1-2 | CASRLSGTNIPPTYGYTF | 18 | TRAV19 | TRAJ49 | CALSDRTGNQFYF | 13 |
| 4 | TRBV4-1 | TRBJ2-7 | CASSRPPTSSSYEQYF | 16 | * | |||
| 5 | TRBV12-3/12-4 | TRBJ1-2 | CASSVQGLGYGYTF | 14 | * | |||
| 6 | TRBV4-1 | TRBJ2-7 | CASSPGQTSSYEQYF | 15 | * | |||
| 7 | TRBV6-2 | TRBJ1-6 | CASSFTQGSPLHF | 13 | TRAV20 | TRAJ37 | CAVAGSGNTGKLIF | 14 |
| 8 | TRBV6-5 | TRBJ1-2 | CASSYRGANGYTF | 13 | TRAV12-3 | TRAJ42 | WDYGGSQGNLIF | 12 |
| 9 | TRBV27 | TRBJ1-1 | CASSPRGYNTEAFF | 14 | TRAV26-2 | TRAJ54 | CILSLIIQGAQKLVF | 15 |
| 10 | TRBV27 | TRBJ1-5 | CASSFRGPASQPQHF | 15 | TRAV12-2 | TRAJ40 | CGTGSGTYKYIF | 12 |
| 11 | TRBV18 | TRBJ1-2 | CASSPDRQGVEYTF | 14 | TRAV13-1 | TRAJ47 | CAAMCKLVF | 9 |
| 12 | TRBV12-3 | TRBJ2-3 | CASSLGRDESTDTQYF | 16 | TRAV22 | TRAJ6 | CAVGGGGSYIPTF | 13 |
| 13 | TRBV12-3 | TRBJ2-1 | CASRQQGVGYNEQFF | 15 | TRAV17 | TRAJ11 | CATALISGYSTLTF | 14 |
| 14 | TRBV27 | TRBJ2-7 | CASRYRGAYEQYF | 13 | TRAV13-1 | TRAJ54 | CASLGIIQGAQKLVF | 15 |
| 15 | TRBV3-1 | TRBJ2-2 | CASSQLTGGVTGELFF | 16 | TRAV12-3 TRAV20 |
TRAJ40 TRAJ47 |
CATRTTSGTYKYIF CAVQVLMEYGNKLVF |
14 15 |
| 16 | TRBV20-1 | TRBJ2-2 | CSARDPLAGVRTGELFF | 17 | * | |||
| 17 | TRBV7-8 | TRBJ2-2 | CASSLYGGNTGELFF | 15 | TRAV8-2 | TRAJ4 | CVVSVAFSGGYNKLIF | 16 |
| 18 | TRBV4-3 | TRBJ1-6 | CASSQDQGGLGYNSPLHF | 18 | TRAV38-2 | TRAJ40 | CAYRFSGTYKYIF | 13 |
| 19 | TRBV7-2 | TRBJ1-1 | CASSFRRGSMNTEAFF | 16 | TRAV29 | TRAJ33 | CAASPSDSNYQLIW | 14 |
| 20 | TRBV4-3 | TRBJ2-7 | CASSQYYEQYF | 11 | * | |||
| 21 | TRBV20-1 | TRBJ2-2 | CSASRGDPTGELFF | 14 | TRAV4 | TRAJ18 | CLVPRGSTLGRLYF | 14 |
| 22 | TRBV4-3 | TRBJ2-3 | CASSQETGPTQYF | 13 | TRAV2 | TRAJ8 | CAVEDHGTGFQKLVF | 15 |
| 23 | TRBV4-3 | TRBJ2-3 | CASSKMGPRTDTQYF | 15 | TRAV12-3 | TRAJ33 | CAMSARSNYQLIW | 13 |
| 24 | TRBV5-8 | TRBJ2-5 | CASTEGIQETQYF | 13 | TRAV8-2 | TRAJ20 | CAVSEAYKLSF | 11 |
*
, sequence not detected