Table 2.
Prespecified definitions for baseline conditions
| Condition | ICD-10/ATC codes | Diagnosis type | Inpatient/outpatient/minimum required length of stay/other criteria | Timeframe |
|---|---|---|---|---|
| Chronic obstructive pulmonary disease | J42-J44 | A or B | Any | ≤ 10 years prior to randomization |
| Asthma | J45 | A or B | Any | ≤ 10 years prior to randomization |
| Chronic lung disease | A15-A16, D860, E84, J42-J47, J84, Z942 | A or B | Any | ≤ 10 years prior to randomization |
| Diabetes (ICD-10) | E10-E14 | A or B | Any | ≤ 10 years prior to randomization |
| Diabetes (ATC) | A10 | – | ≥ 1 claimed prescription | ≤ 180 days prior to randomization |
| Hypertension (ICD-10) | I10-I15 | A or B | Any | ≤ 10 years prior to randomization |
| Hypertension (ATC) |
Diuretics: C03 β-blockers: C07 Calcium blockers: C08 Renin-angiotensin system inhibitors: C09 |
– | ≥ 1 claimed prescription from ≥ 2 drug classes | ≤ 180 days prior to randomization |
| Dyslipidemia (ATC) | C10 | – | ≥ 1 claimed prescription | ≤ 180 days prior to randomization |
| Ischemic heart disease | I20-I25 | A or B | Any | ≤ 10 years prior to randomization |
| Myocardial infarction | I21 | A or B | Any | ≤ 10 years prior to randomization |
| Heart failure | I50 | A or B | Any | ≤ 10 years prior to randomization |
| Other cardiomyopathy | I42-I43 | A or B | Any | ≤ 10 years prior to randomization |
| Atrial fibrillation | I48 | A or B | Any | ≤ 10 years prior to randomization |
| Other arrhythmia | I44-I47, I49 | A or B | Any | ≤ 10 years prior to randomization |
| Valvular disease | I34-I37 | A or B | Any | ≤ 10 years prior to randomization |
| Pericarditis | I30-I31 | A or B | Any | ≤ 10 years prior to randomization |
| Endocarditis | I33, I38-I39 | A or B | Any | ≤ 10 years prior to randomization |
| Myocarditis | I40-I41 | A or B | Any | ≤ 10 years prior to randomization |
| Pulmonary heart disease | I26-I28 | A or B | Any | ≤ 10 years prior to randomization |
| Cerebrovascular disease | I60-I69 | A or B | Any | ≤ 10 years prior to randomization |
| Peripheral vascular disease | I70, I74 | A or B | Any | ≤ 10 years prior to randomization |
| Congenital heart disease | Q20-Q26 | A or B | Any | ≤ 10 years prior to randomization |
| Chronic cardiovascular disease | I20-I28, I34-I37, I42-I50, I60-I69, I70, I74, Q20-Q26 | A or B | Any | ≤ 10 years prior to randomization |
| Cancer | C00-C97 (not C44) | A or B | Any | ≤ 10 years prior to randomization |
| Chronic kidney disease | E102, E112, E132, E142, I120, N02-N08, N11-N12, N14, N18-N19, N26, N158-N160, N162-N164, N168, M300, M313, M319, M321B, Q612-Q613, Q615, Q619, T858-T859, Z992 | A or B | Any | ≤ 10 years prior to randomization |
| Liver disease | B15-B19, K70-K77, C22, I982, Z944, D684C, Q618 | A or B | Any | ≤ 10 years prior to randomization |
| Immunodeficiency (ICD-10) | B20-B24, D80-D84, D89, O987, Z21, Z940-Z944, Z948A | A or B | Any | ≤ 10 years prior to randomization |
| Immunodeficiency (ATC) | H02AB, L04 | – | ≥ 1 claimed prescription | ≤ 180 days prior to randomization |
| Neurological/neuromuscular disease | F00-F03, G10-G14, G20-G23, G30-G32, G35-G37, G40-G41, G70-G73, G80-G83, G91-G95 | A or B | Any | ≤ 10 years prior to randomization |
| Dementia | F00-F03, G30, G311-G312, | A or B | Any | ≤ 10 years prior to randomization |
| Rheumatic disease | M05-M06, M32-M34, M353 | A or B | Any | ≤ 10 years prior to randomization |
All baseline conditions are defined from ICD-10 codes except for diabetes, hypertension, dyslipidemia, and immunodeficiency, where ATC codes are also used. ICD International Classification of Diseases, ATC anatomic therapeutic chemical