TABLE 1.
Intranasal perfusion of USPIO-loaded mouse astrocyte-derived EVs.
| Day | Intranasal perfusion of ADEVs and MRI scan |
|---|---|
| Day 0 | • MRI pre-scan on 6 mice |
| • Wait 1 h and intranasal perfusion of 2 × 1012 USPIO-labeled ADEVs in 50 μL PBS | |
| Day 1 | • Intranasal perfusion of 2 × 1012 USPIO-labeled ADEVs in 50 μL PBS |
| • Wait 1 h and MRI scan | |
| • Intranasal perfusion of 2 × 1012 USPIO-labeled ADEVs in 50 μL PBS | |
| Day 2 | • Intranasal perfusion of 2 × 1012 USPIO-labeled ADEVs in 50 μL PBS |
| • Wait 1 h and MRI scan | |
| • Intranasal perfusion of 2 × 1012 USPIO-labeled ADEVs in 50 μL PBS | |
| Day 3 | • Intranasal perfusion of 2 × 1012 USPIO-labeled ADEVs in 50 μL PBS |
| • Wait 1 h and MRI scan | |
| • Intranasal perfusion of 2 × 1012 USPIO-labeled ADEVs in 50 μL PBS. | |
| Day 4 | • Intranasal perfusion of 2 × 1012 USPIO-labeled ADEVs in 50 μL PBS |
| • Wait 1 h and MRI scan |