| Methods |
RCT
Open
1991‐1994 |
| Participants |
Number: 102 patients (118 episodes)
Age: med58, range 15‐75 |
| Interventions |
ceftazidime 2grx3
versus
imipenem 500mgx4 |
| Outcomes |
Overall and infection‐related mortality ‐ at end of treatment
Clinical and microbiological failure
Drug modifications
Adverse events |
| Notes |
Spain |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Adequate sequence generation? |
Low risk |
The randomization code was generated by computer |
| Allocation concealment? |
Low risk |
The allocation was performed centrally by telephone call to our secretariat |
| Blinding?
All outcomes |
High risk |
No blinding were used |
| Incomplete outcome data addressed?
All‐cause mortality |
High risk |
13% dropouts |
| Incomplete outcome data addressed?
Treatment failure |
High risk |
Number of dropouts (13%) known per study group |
| Free of other bias? |
High risk |
Unit of randomization = episodes; patients to episodes ratio 0.86 |
