Bickers 1990.

Methods	RCT Open
Participants	Number: 135 patients Age: mean 41
Interventions	cefoperazone‐sulbactam 2gr/1grx2 versus imipenem 500mgx4
Outcomes	Overall and infection‐related mortality ‐ at 7 days after end of treatment Clinical failure Drug modifications Adverse events
Notes	USA
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Unclear risk	No description
Allocation concealment?	Unclear risk	No description
Blinding? All outcomes	High risk	No blinding used
Incomplete outcome data addressed? All‐cause mortality	Low risk
Incomplete outcome data addressed? Treatment failure	Low risk
Free of other bias?	Low risk	Unit of randomization = patients