| Methods |
RCT
Open
1991‐1994 |
| Participants |
Number: 248 patients
Age: mean 42, range 14‐78 |
| Interventions |
meropenem 1grx3
versus
ceftazidime 2grx3 |
| Outcomes |
Overall and infection‐related mortality ‐ at end of treatment
Clinical and microbiological failure
Superinfection
Drug modifications |
| Notes |
MC Europe |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Adequate sequence generation? |
Low risk |
Computer generated sequence |
| Allocation concealment? |
Low risk |
Allocation to one or the other regimen was achieved by an investigator opening the next in a sequence of sealed envelopes containing numbers generated by a computer in each center. sealed envelopes, opaque not mentioned. |
| Blinding?
All outcomes |
High risk |
No blinding used |
| Incomplete outcome data addressed?
All‐cause mortality |
High risk |
10% dropouts |
| Incomplete outcome data addressed?
Treatment failure |
High risk |
Number of dropouts (10%) known per study group |
| Free of other bias? |
High risk |
Unit of randomization = episodes; patients to episodes ratio 0.73 |
