| Methods |
RCT
Open |
| Participants |
Number: 528 patients
Age not given |
| Interventions |
piperacillin‐tazobactam 4.5grx4
versus
cefepime 2grx3 |
| Outcomes |
Overall and infection‐related mortality ‐ at 7 days following end of treatment
Clinical and microbiological failure
Drug modifications |
| Notes |
MC USA,Canada,Australia |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Adequate sequence generation? |
Low risk |
Computer generated sequence |
| Allocation concealment? |
Low risk |
Central |
| Blinding?
All outcomes |
High risk |
No blinding used |
| Incomplete outcome data addressed?
All‐cause mortality |
Low risk |
|
| Incomplete outcome data addressed?
Treatment failure |
Low risk |
|
| Free of other bias? |
Low risk |
Unit of randomization = patients |
