| Methods |
RCT
Open
2000‐2001 |
| Participants |
Number: 95 patients (120 episodes)
Age: mean 5.5, range 0.3‐15.5 |
| Interventions |
cefepime 25mg/kgx2
versus
ceftazidime 25mg/kgx2 |
| Outcomes |
Overall and infection‐related mortality ‐ at 30 days after end of treatment
Clinical and microbiological failure
Superinfection
Drug modifications
Adverse events |
| Notes |
Taiwan |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Adequate sequence generation? |
Unclear risk |
Patients were randomized in a 1:1 ratio and stratified by type of underlying malignancy |
| Allocation concealment? |
Unclear risk |
No description |
| Blinding?
All outcomes |
High risk |
No blinding used |
| Incomplete outcome data addressed?
All‐cause mortality |
High risk |
20% dropouts |
| Incomplete outcome data addressed?
Treatment failure |
High risk |
Number of dropouts (3%) known per study group |
| Free of other bias? |
High risk |
Unit of randomization = episodes; patients to episodes ratio 0.79 |
