| Methods |
RCT
Open |
| Participants |
Number: 80 episodes
Age: mean 45.6 |
| Interventions |
piperacillin‐tazobactam 4.5grX3
versus
meropenem 1grX3 |
| Outcomes |
Overall and infection‐related mortality ‐ at end of treatment
Clinical and microbiological failure |
| Notes |
UK
Study terminated early because of problems with supply of one of the study drugs and therefore unpublished. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Adequate sequence generation? |
Unclear risk |
No description |
| Allocation concealment? |
Unclear risk |
No description |
| Blinding?
All outcomes |
High risk |
Blinding not used |
| Incomplete outcome data addressed?
All‐cause mortality |
High risk |
2% dropouts |
| Incomplete outcome data addressed?
Treatment failure |
High risk |
Number of dropouts (2%) known per study group |
| Free of other bias? |
High risk |
Unit of randomization = episodes; number of patients unknown |
