| Methods |
RCT
Assessor blinded
1986‐1988 |
| Participants |
Number:
number randomised unknown; 378 episodes assessed
Age: med 46, range: 16‐84 |
| Interventions |
imipenem 12.5mg/kg x 4
versus
ceftazidime 1grx6 |
| Outcomes |
Clinical and microbiological failure
Superinfection
Drug modifications
Adverse events |
| Notes |
USA |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Adequate sequence generation? |
Low risk |
Patients were randomly assigned using a computer‐generated sequence of numbers |
| Allocation concealment? |
Low risk |
No description, but previous trials in the center were conducted using the pharmacy as the center of randomization and allocation was disclosed only after patients' entered the trial |
| Blinding?
All outcomes |
High risk |
Response to therapy was evaluated by an investigator who was not involved in the patient's care and who was unaware of the regimen used |
| Incomplete outcome data addressed?
All‐cause mortality |
Unclear risk |
Mortaliy not reported in study |
| Incomplete outcome data addressed?
Treatment failure |
Unclear risk |
Number randomized not specified |
| Free of other bias? |
High risk |
Unit of randomization = episodes; number of patients unknown |
