Shah 1996.

Methods	RCT Open 1992‐1994
Participants	Number: 61 patients (66 episodes) Age: imipenem mean 8.6 range (1‐28); meropenem 9.8 (1‐22)
Interventions	imipenem/cilastatin 1grX3
Outcomes	meropenem 1grX3
Notes	Germany
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Low risk	Computer generated sequence
Allocation concealment?	Low risk	Sealed opaque envelopes used
Blinding? All outcomes	High risk	Blinding not used
Incomplete outcome data addressed? All‐cause mortality	Low risk
Incomplete outcome data addressed? Treatment failure	Low risk
Free of other bias?	High risk	Unit of randomization = episodes; patients to episodes ratio 0.92