Tamura 2002.

Methods	RCT Open 1999‐2000
Participants	Number: 83 patients (the trial included a third arm with 82 patients that received combination therapy and was excluded from this review) Age: mean 52.4
Interventions	cefepime 1‐2grx2 versus carbapenem (imipenem, panipenem, or meropenem) 0.5‐1grX2
Outcomes	Overall mortality ‐ at 30 days after end of treatment Clinical failure Adverse events
Notes	MC Japan
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Low risk	Randomisation by table of random numbers
Allocation concealment?	Low risk	Sealed envelopes, opaque not mentioned
Blinding? All outcomes	High risk	Blinding not used
Incomplete outcome data addressed? All‐cause mortality	Low risk
Incomplete outcome data addressed? Treatment failure	High risk	number of dropouts (7%) known per study group
Free of other bias?	Low risk