Winston 1998.

Methods	RCT Open
Participants	Number: 209 patients (213 episodes) Age: med 43, range 16‐81
Interventions	sulbactam/cefoperazone 2gr/4grx2 versus imipenem 500mgx4
Outcomes	Clinical and microbiological failure Superinfection Adverse events
Notes	USA
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Unclear risk	No description
Allocation concealment?	Unclear risk	No description
Blinding? All outcomes	High risk	Blinding not used
Incomplete outcome data addressed? All‐cause mortality	Unclear risk	Mortaliy not reported in study
Incomplete outcome data addressed? Treatment failure	Unclear risk	Denominator refers to sites of infection rather than patient or episode
Free of other bias?	High risk	Unit of randomization = episodes; patients to episodes ratio 0.98. Unit used for analysis sites of infection

RCT ‐ randomised controlled trial (see table of study quality assessment for further details)