TABLE 1.
Correlations of SNPs with weight loss (first 6 mo of intervention) and weight regain (6 mo to ~2 y) in the Look AHEAD and DPP trials
| Weight loss | Weight regain | |
|---|---|---|
| BDNF | ||
| rs6265 (33) | N.S. | 0.55 (0.21) kg/allele/y, P = 0.011 |
| FTO | ||
| rs3751812 (34) | N.S. | 1.56 (0.55) kg/allele/3 y, P < 0.005a |
| rs9939609 (34) | N.S. | 1.03 (0.52) kg/allele/3 y, P < 0,049a |
| rs9922708 (34) | N.S. | 1.38 (0.55) kg/allele/3 y, P < 0.012a |
| KCTD15 | ||
| rs29941 (33) | 0.50 (0.24) kg/allele/y, P = 0.041b | N.S. |
| MTIF3 | ||
| rs1885988 (34,35) | −0.73 (−1.30 to −0.15) kg/allele/3 y, P = 0.009c | N.S. |
| NEGR1 | ||
| rs2815752 (33) | −0.79 (0.29) kg/allele/2 y, P = 0.006b | −0.35 (0.16) kg/allele/y, P = 0.034 |
| PPARγ | ||
| rs1801282 (33) | −0.63 (0.22) kg/allele/0.5 y, P = 0.005 | −0.79 (0.27) kg/allele/y, P = 0.004 |
| TFA2β | ||
| rs2272903 (34) | −0.93 (0.31) kg/allele/2 y, P = 0.003 −0.64 (0.31) kg/allele/y, P = 0.037c | N.S. |
| TMEM18 | ||
| rs6548238 (33) | 0.62 (0.31) kg/allele/y, P = 0.044b | N.S. |
Data refer to the mean (SD) number of kilograms of weight gain that can be attributed to each “dose” of the relevant allele over the specified unit of time (0.5-3 y depending upon study).
BDNF, brain-derived neurotrophic factor; FTO, fat mass and obesity-associated gene; KCTD15, potassium channel tetramerization domain containing 15; MTIF3, mitochondrial translational initiation factor 3; TFA2β, transcription initation factor IIE subunit β; TMEM18, transmembrane protein 18; NEGR1, neuronal growth regulator 1; PPARγ, peroxisome proliferator activated receptor γ; DPP, Diabetes Prevention Program; DSE, Diabetes Support and Education; ILI, intensive Lifestyle Intervention; N.S., not significant; PPARG, XXX; SNP, single-nucleotide polymorphism.
Only significant in the DSE group of the Look AHEAD trial.
Only significant in the metformin-treated group of the DPP trial.
Only significant in the ILI group of the Look AHEAD trial.