Table II.
List of meta-analysed dysregulated genes after application of Robust Rank Aggregation (RRA) method.
| Gene symbol | Gene name | RRA score | FDR |
|---|---|---|---|
| FOSB ↑ | FosB Proto-Oncogene, AP-1 Transcription Factor Subunit | 4.12E−05 | 0.304 |
| S100A8 ↑ | S100 Calcium Binding Protein A8 | 0.00013341 | 0.492 |
| FOS ↑ | Fos Proto-Oncogene, AP-1 Transcription Factor Subunit | 0.00086691 | 1 |
| GUCY1B2 ↑↓ | Guanylate Cyclase 1 Soluble Subunit Beta 2 (Pseudogene) | 0.00157031 | 1 |
| CFB ↑ | Complement Factor B | 0.00211388 | 1 |
| IL32 ↑ | Interleukin 32 | 0.00247818 | 1 |
| SELL ↑↓ | Selectin L | 0.00329218 | 1 |
| CD4 ↑↓ | CD4 Molecule | 0.00421945 | 1 |
| EGR1 ↑ | Early Growth Response 1 | 0.00455357 | 1 |
| CYR61 ↑ | Cysteine-rich angiogenic inducer 61 | 0.00472531 | 1 |
| PPBP ↑ | Pro-Platelet Basic Protein | 0.0048764 | 1 |
| CASP5 ↑ | Caspase 5 | 0.0048764 | 1 |
| WT1 ↓ | WT1 Transcription Factor | 0.0048764 | 1 |
| RP11-319E12.2 ↑ | Clone-based (Vega) gene | 0.0048764 | 1 |
| SOCS1 ↑ | Suppressor of cytokine signalling 1 | 0.00724011 | 1 |
| IL17A ↑ | Interleukin 17A | 0.00974949 | 1 |
| LTB4R2 ↑ | Leukotriene B4 Receptor 2 | 0.00974949 | 1 |
| htMART ↑ | Putative mono-ADP-ribosyltransferase | 0.00974949 | 1 |
| ATP7B ↓ | ATPase Copper Transporting Beta | 0.00974949 | 1 |
| IGFBP1 ↑ | Insulin Like Growth Factor Binding Protein 1 | 0.00974949 | 1 |
| NR4A1 ↑ | Nuclear Receptor Subfamily 4 Group A Member 1 | 0.01027371 | 1 |
| CTNNB1 ↑↓ | Catenin Beta 1 | 0.01029457 | 1 |
| C4BPA ↑↓ | Complement Component 4 Binding Protein Alpha | 0.01211943 | 1 |
| HES1 ↑ | Hes Family BHLH Transcription Factor 1 | 0.01440884 | 1 |
| CXCL10 ↑ | C-X-C Motif Chemokine Ligand 10 | 0.01461928 | 1 |
| PTAFR ↑ | Platelet Activating Factor Receptor | 0.01461928 | 1 |
| NAB50 ↑ | RNA-binding protein CUG-BP/hNab50 | 0.01461928 | 1 |
| SLC1A1 ↓ | Solute Carrier Family 1 Member 1 | 0.01461928 | 1 |
| LRRC26 ↓ | Leucine Rich Repeat Containing 26 | 0.01461928 | 1 |
| LTBR ↑↓ | Lymphotoxin Beta Receptor | 0.01819934 | 1 |
| IL7R ↑ | Interleukin 7 Receptor | 0.01948577 | 1 |
| VSTM2L ↑ | V-Set and Transmembrane Domain Containing 2 Like | 0.01948577 | 1 |
| BSEP ↑ | Bile Salt Export Pump | 0.01948577 | 1 |
| SOS1 ↑↓ | SOS Ras/Rac Guanine Nucleotide Exchange Factor 1 | 0.01948577 | 1 |
| C1orf63 ↓ | Arginine And Serine Rich Protein 1 | 0.01948577 | 1 |
| SERPINB2 ↑ | Serpin Family B Member 2 | 0.01948577 | 1 |
| CD19 ↑ | CD19 Molecule | 0.02434897 | 1 |
| ASB2 ↑ | Ankyrin Repeat and SOCS Box Containing 2 | 0.02434897 | 1 |
| VDAC1P1 ↑ | Voltage Dependent Anion Channel 1 Pseudogene 1 | 0.02434897 | 1 |
| SMG1 ↓ | SMG1 Nonsense Mediated MRNA Decay Associated PI3K Related Kinase | 0.02434897 | 1 |
| CFH ↑ | Complement Factor H | 0.02920887 | 1 |
| GZMA ↑ | Granzyme A | 0.02920887 | 1 |
| NEAT1 ↑↓ | Nuclear Paraspeckle Assembly Transcript 1 | 0.02920887 | 1 |
| ZIC2 ↑ | Zic Family Member 2 | 0.02920887 | 1 |
| SLC6A7 ↓ | Solute Carrier Family 6 Member 7 | 0.02920887 | 1 |
| EREG ↑ | Epiregulin | 0.02920887 | 1 |
| MPPED2 ↑↓ | Metallophosphoesterase Domain Containing 2 | 0.02928315 | 1 |
| ANK3 ↑↓ | Ankyrin 3 | 0.03015014 | 1 |
| IER3 ↑↓ | Immediate Early Response 3 | 0.03035717 | 1 |
| CXCR2 ↑ | C-X-C Motif Chemokine Receptor 2 | 0.03406547 | 1 |
| LOC389332 ↑ | Small Integral Membrane Protein 32 | 0.03406547 | 1 |
| TRPM6 ↓ | Transient Receptor Potential Cation Channel Subfamily M Member 6 | 0.03406547 | 1 |
| CA1 ↑ | Carbonic Anhydrase 1 | 0.03406547 | 1 |
| ITGAL ↑ | Integrin Subunit Alpha L | 0.03406547 | 1 |
| MMP27 ↑ | Matrix Metallopeptidase 27 | 0.03406547 | 1 |
| HTRA3 ↑ | HtrA Serine Peptidase 3 | 0.03521064 | 1 |
| WAS ↑↓ | WASP Actin Nucleation Promoting Factor | 0.0375287 | 1 |
| CXCL9 ↑ | C-X-C Motif Chemokine Ligand 9 | 0.03891879 | 1 |
| SAP30L ↑↓ | SAP30 Like | 0.03891879 | 1 |
| PMS7 ↑ | HPMS7 protein | 0.03891879 | 1 |
| PTPN11 ↓ | Protein Tyrosine Phosphatase Non-Receptor Type 11 | 0.03891879 | 1 |
| ABP1 ↑ | Actin-binding protein | 0.03891879 | 1 |
| S100A7 ↓ | S100 Calcium Binding protein A7 | 0.03891879 | 1 |
| SAMD14 ↑ | Sterile Alpha Motif Domain Containing 14 | 0.04376881 | 1 |
| PRIM2 ↑ | DNA primase large subunit | 0.04376881 | 1 |
| DYNLL1 ↑ | Dynein Light Chain LC8-Type 1 | 0.04376881 | 1 |
| CTSW ↑ | Cathepsin W | 0.04376881 | 1 |
| MMP10 ↑ | Matrix Metallopeptidase 10 | 0.04376881 | 1 |
| KLRG2 ↑ | Killer Cell Lectin Like Receptor G2 | 0.04861554 | 1 |
| ORAI2 ↑ | ORAI Calcium Release-Activated Calcium Modulator 2 | 0.04861554 | 1 |
| IFNA21 ↑ | Interferon Alpha 21 | 0.04861554 | 1 |
| MAP3K8 ↓ | Mitogen-Activated Protein Kinase Kinase Kinase 8 | 0.04861554 | 1 |
| CCL3 ↑ | C-C Motif Chemokine Ligand 3 | 0.04861554 | 1 |
| LEFTY2 ↑ | Left-Right Determination Factor 2 | 0.04861554 | 1 |
For each gene, corresponding RRA score and false discovery rate (FDR) multiple correction values are presented. Arrows indicate the up- (↑) and down-regulated (↓) expression of the transcripts in the original datasets. Please note that for some genes, both up- and down-regulated expression can be observed among different studies (↑↓).