Table 3.

Aziridine Substrate Scope for Tryptamine Synthesis^a

entry	aziridine	time (h)	yield (%)b	ee (%)c
1		48	88	97
2		72	81	98
3		48	79	94
4		72	62	97
5		48	73	95
6		48	64	93
7		120	53	91
8		168	25	53

^aReaction conditions: aziridine (0.2 mmol), 2-methylindole (0.8 mmol), catalyst 9 (0.02 mmol), and 100 mg of 4 Å powdered molecular sieves in α,α,α-trifluorotoluene (1 mL) were heated to 40 °C for the time indicated.

^bIsolated yield from two or more runs.

^cDetermined by HPLC.