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. 2022 Apr 7;13:876555. doi: 10.3389/fimmu.2022.876555

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Copyright © 2022 Guo, Semerci, De Assis, Kayisli, Schatz, Steffensen, Guzeloglu-Kayisli and Lockwood

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of SARS-CoV-2 entry receptor ACE2 and TMPRSS2 mRNA levels among various decidual (maternal) and placental (fetal) cell types at the maternal-fetal interface. Expression levels of ACE2 (A) and TMPRSS2 (B) in human term cytotrophoblast (CTBs), syncytiotrophoblast (STBs), term decidual cell (TDCs), first trimester decidual cell (FTDCs), and human endometrial stromal cell (HESCs) cultures; Expression levels of ACE2 and TMPRSS2 in trophoblastic cell lines HTR8 and JEG3 (C); as well as expression levels of ACE2 in placental microvascular endothelial (PMVECs) and human endometrial endothelial cell (HEECs) cultures (D) by qPCR. Bars represent mean ± SEM, n=4; * P<0.05 vs. CTB or STB (A); * P<0.05 vs. HTR8 (C); * P<0.05 vs. HEECs (D).