Fig. 4.

The associations of NMP with TMB, PD-L1, and drug sensitivity. A Correlation between NMP and TMB. Every blue point indicates the data of one sample, and the pink line is a smoothing spline illustrating the trend of association between NMP and TMB. B Correlation between NMP and PD-L1 expression (TPS, IPS, and CPS). Every blue point indicates the data of one sample, and the orange line is a smoothing spline illustrating the trend of association between NMP and PD-L1 expression. C Representative images of PD-L1 staining. D Drug sensitivity of the five MSI-H STAD cell lines. Abbreviations: CPS, combined positive score; IPS, immune proportion score; NMP, number of mutated members in the PI3K-AKT-mTOR pathway; PD-1, programmed death-1; PD-L1, programmed death-ligand 1; TMB, tumor mutational burden; TPS, tumor proportion score