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. 2022 Apr 21;20:133. doi: 10.1186/s12916-022-02327-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Association between NMP and response to ICI in dMMR/MSI-H G/GEJ adenocarcinomas. A Basic clinicopathological characteristics and mutations of the PI3K-AKT-mTOR pathway of the ICI treatment cohort. B, C Association of NMP with tumor mutational burden (B) and PD-L1 CPS score (C). D Bar plot illustrating best response and ROC curve of the NMP to predict ORR. The NMP of each patient is labeled with red (NMP, 0), blue (NMP, 1), and green (NMP > 1). E, F Kaplan-Meier curves of PFS (E) and OS (F) in the NMP-low (0/1) and NMP-high (> 1) patients. G Subgroup analysis of PFS. H Association between NMP and DTICs. I. Representative images of DTICs. Abbreviations: AUC, area under curve; CI, confidence interval; CPS, combined positive score; CR, complete response; DTIC, density of tumor-infiltrating immune cells; ECOG, Eastern Cooperative Oncology Group; HR, hazard ratio; NA, not applicable; ORR, objective response rate; OS, overall survival; PD, progressive disease; PD-L1, programmed death-ligand 1; PFS, progression-free survival; PR, partial response; SD, stable disease; WT, wildtype