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. 2022 Apr 20;20:195. doi: 10.1186/s12951-022-01403-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — A Histopathological analysis of Masson’s trichrome staining of wounds in mice on day 8 after different treatments. B Corresponding epithelial gap in each group after the treatment. C Representative histological images of CD31 and VEGF immunofluorescence staining of wound tissue in each group at the end of the 8 days’ treatments. D Western blot analyses of CD31 and HIF-1α expressions in wound of mice in each group at the end of 8 days’ treatments. E Corresponding quantitative level of CD31 and HIF-1α expressions in each group. F Representative H&E staining images of major organs after different treatments