Figure 2.

S1 specific reactive T cells before, 1-month and 3-month after booster BNT162b mRNA vaccine dose in NH residents.

Individual values and median [interquartile range (IQR)] are shown. (A) S1 specific reactive T cells in NH residents without (naive, blue) or with (recovered, red) prior COVID-19 before initial vaccination (Dose 1, D1; Dose 2, D2; time interval between D1-D2: 21 to 28 days), according to time (in months), from before initial vaccination to 3-month post booster vaccine dose. Mann-Whitney U test was performed to compare naive and recovered residents. (B) Comparison of S1 reactive T cells before (pre-boost) and 1- and 3-month post-booster vaccine dose in COVID-19 naive NH residents (blue) and in COVID-19 recovered residents (red). Wilcoxon signed rank test was used for within-subjects comparisons. ****p-value < 0·0001, ** p-value < 0·01, ns, not significant